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. 1986 Nov 11;14(21):8373–8386. doi: 10.1093/nar/14.21.8373

Genomic localization of hepatitis B virus in a human hepatoma cell line.

M Zerial, J Salinas, J Filipski, G Bernardi
PMCID: PMC311865  PMID: 3024104

Abstract

The integration of hepatitis B viral sequences in the human hepatoma Alexander cell line has been investigated after fractionation of the cell line DNA by centrifugation in a Cs2SO4/BAMD (3,6-(bis-acetato mercurimethyl) dioxane) density gradient. Eight out of nine integrated viral sequences were localized in DNA component H3, which only represents 4% of the human genome and matches the base composition of HBV sequences. These results indicate a targeting and/or a higher stability of the latter in a specific, small compartment of the host genome.

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Selected References

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