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. 1992 Mar 11;20(5):1087–1091. doi: 10.1093/nar/20.5.1087

Evolutionary variation of the CCAAT-binding transcription factor NF-Y.

X Y Li 1, R Mantovani 1, R Hooft van Huijsduijnen 1, I Andre 1, C Benoist 1, D Mathis 1
PMCID: PMC312095  PMID: 1549471

Abstract

NF-Y is a CCAAT-specific transcription factor thought to be involved in the regulation of a variety of eukaryotic genes. It shows a striking sequence similarity with the yeast factor HAP2/3. In an attempt to trace back its evolutionary history, we succeeded in isolating NF-Y cDNA clones from a plant and from several species of vertebrates. The patterns of sequence conservation delineate potential functional domains: A central, highly conserved, domain likely responsible for DNA-binding and subunit interaction; more evolutionarily flexible flanking regions, in which variability is clustered, individualizing conserved glutamine or acidic amino-acids putatively involved in protein-protein contacts.

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Selected References

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