Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1990 Nov;58(11):3807–3809. doi: 10.1128/iai.58.11.3807-3809.1990

Combined inheritance of epithelial and erythrocyte receptors for Haemophilus influenzae.

L van Alphen 1, C Levene 1, L Geelen-van den Broek 1, J Poole 1, M Bennett 1, J Dankert 1
PMCID: PMC313732  PMID: 1977707

Abstract

Haemophilus influenzae type b expressing fimbriae showed no adherence to buccal epithelial cells and no agglutination of erythrocytes from three AnWj-negative siblings in one family. Hemagglutination of erythrocytes from 13 AnWj-positive members of the same family and from 24 controls was normal, and H. influenzae adhered well to buccal epithelial cells from them. These data indicate that the expression of epithelial and erythrocyte receptors for H. influenzae is inherited concomitantly. Combined with previous data (L. van Alphen, J. Poole, L. Geelen, and H. Zanen, Infect. Immun. 55:2355-2358, 1987), the results show that the receptor molecules on the surfaces of the epithelial cell and the erythrocyte are different but that the binding sites for the fimbriae of H. influenzae are similar.

Full text

PDF
3809

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bock K., Karlsson K. A., Strömberg N., Teneberg S. Interaction of viruses, bacteria and bacterial toxins with host cell surface glycolipids. Aspects on receptor identification and dissection of binding epitopes. Adv Exp Med Biol. 1988;228:153–186. doi: 10.1007/978-1-4613-1663-3_7. [DOI] [PubMed] [Google Scholar]
  2. Guerina N. G., Langermann S., Clegg H. W., Kessler T. W., Goldman D. A., Gilsdorf J. R. Adherence of piliated Haemophilus influenzae type b to human oropharyngeal cells. J Infect Dis. 1982 Oct;146(4):564–564. doi: 10.1093/infdis/146.4.564. [DOI] [PubMed] [Google Scholar]
  3. Marsh W. L., Brown P. J., DiNapoli J., Beck M. L., Wood M., Wojcicki R., de la Camara C. Anti-Wj: an autoantibody that defines a high-incidence antigen modified by the In(Lu) gene. Transfusion. 1983 Mar-Apr;23(2):128–130. doi: 10.1046/j.1537-2995.1983.23283172849.x. [DOI] [PubMed] [Google Scholar]
  4. Pichichero M. E. Adherence of Haemophilus influenzae to human buccal and pharyngeal epithelial cells: relationship to pilation. J Med Microbiol. 1984 Aug;18(1):107–116. doi: 10.1099/00222615-18-1-107. [DOI] [PubMed] [Google Scholar]
  5. Poole J., Giles C. M. Observations on the Anton antigen and antibody. Vox Sang. 1982;43(4):220–222. doi: 10.1111/j.1423-0410.1982.tb00015.x. [DOI] [PubMed] [Google Scholar]
  6. Poole J., Van Alphen L. Haemophilus influenzae receptor and the AnWj antigen. Transfusion. 1988 May-Jun;28(3):289–289. doi: 10.1046/j.1537-2995.1988.28388219164.x. [DOI] [PubMed] [Google Scholar]
  7. Sable N. S., Connor E. M., Hall C. B., Loeb M. R. Variable adherence of fimbriated Haemophilus influenzae type b to human cells. Infect Immun. 1985 Apr;48(1):119–123. doi: 10.1128/iai.48.1.119-123.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Stull T. L., Mendelman P. M., Haas J. E., Schoenborn M. A., Mack K. D., Smith A. L. Characterization of Haemophilus influenzae type b fimbriae. Infect Immun. 1984 Dec;46(3):787–796. doi: 10.1128/iai.46.3.787-796.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. van Alphen L., Poole J., Geelen L., Zanen H. C. The erythrocyte and epithelial cell receptors for Haemophilus influenzae are expressed independently. Infect Immun. 1987 Oct;55(10):2355–2358. doi: 10.1128/iai.55.10.2355-2358.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. van Alphen L., van Ham M., Geelen-van den Broek L., Pieters T. Relationship between secretion of the Anton blood group antigen in saliva and adherence of Haemophilus influenzae to oropharynx epithelial cells. FEMS Microbiol Immunol. 1989 Jun;1(6-7):357–362. doi: 10.1111/j.1574-6968.1989.tb02421.x. [DOI] [PubMed] [Google Scholar]
  11. van Alphen L., van den Berghe N., Geelen-van den Broek L. Interaction of Haemophilus influenzae with human erythrocytes and oropharyngeal epithelial cells is mediated by a common fimbrial epitope. Infect Immun. 1988 Jul;56(7):1800–1806. doi: 10.1128/iai.56.7.1800-1806.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. van Ham S. M., Mooi F. R., Sindhunata M. G., Maris W. R., van Alphen L. Cloning and expression in Escherichia coli of Haemophilus influenzae fimbrial genes establishes adherence to oropharyngeal epithelial cells. EMBO J. 1989 Nov;8(11):3535–3540. doi: 10.1002/j.1460-2075.1989.tb08519.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES