Abstract
Antimicrobial activity of a crude aflatoxin preparation and of aflatoxin B1 was studied. They were found inactive against common gram-positive and gram-negative bacteria at a concentration of 100 μg/ml. Both samples of aflatoxin did, however, exhibit antimicrobial activity, though narrow and limited, against various strains of Streptomyces and Nocardia. The antibiotic action of aflatoxin B1 was confirmed by bioautogram after thin-layer chromatography. Among seven strains of microorganisms, including aflatoxin-sensitive and -resistant strains, N. asteroides IFM 8 was found to reduce aflatoxin B1, in addition to other minor fluorescent components in the crude preparation.
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