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. 1968 Apr;95(4):1212–1220. doi: 10.1128/jb.95.4.1212-1220.1968

Effect of Chloramphenicol on the Synthesis and Stability of Ribonucleic Acid in Bacillus subtilis

Robert A Lazzarini 1, Edith Santangelo 1
PMCID: PMC315074  PMID: 4967191

Abstract

The effect of chloramphenicol on the synthesis and accumulation of ribonucleic acid (RNA) in Bacillus subtilis was studied. In the presence of chloramphenicol, transfer RNA and ribosomal RNA were synthesized as rapidly 2 to 3 hr after challenge as they were just prior to the addition of the antibiotic. However, under the same conditions, net RNA accumulation ceased after only 30 to 45 min. The failure to accumulate RNA after this time resulted from a rapid degradation of ribosomal RNA synthesized in the presence of chloramphenicol and a slow degradation of mature ribosomes. Since transfer RNA was not appreciably degraded, the ratio of transfer RNA to total RNA increased during the challenge.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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