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. 1969 Jun;98(3):1041–1043. doi: 10.1128/jb.98.3.1041-1043.1969

Effects of Nitrogen Dioxide on Pulmonary Cell Population1

Donald E Gardner a, Robert S Holzman a, David L Coffin a,2
PMCID: PMC315293  PMID: 5788696

Abstract

Studies from this laboratory have shown that ozone produces changes in the number and function of cells obtained by pulmonary lavage. In similar experiments, rabbits exposed to levels of NO2 from ambient to 60 ppm demonstrated increased numbers of polymorphonuclear leukocytes in the lung washings. This phenomenon persisted for more than 72 hr after a single 3-hr exposure. When streptococci were instilled in the lungs of NO2-exposed anesthetized rabbits 30 min before lavage, a pronounced inhibition of phagocytic activity was observed. With these criteria, NO2 appeared less effective than ozone as a pulmonary irritant.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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