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. 1969 Oct;100(1):22–26. doi: 10.1128/jb.100.1.22-26.1969

Transfer of Infectious Drug Resistance in Microbially Defined Mice

Norman D Reed 1, Donna G Sieckmann 1, Carl E Georgi 1
PMCID: PMC315352  PMID: 4898989

Abstract

Germ-free mice were intentionally associated with drug-resistant donor strains of Escherichia coli known to carry R factors and with drug-sensitive recipient strains. In vivo transfer of R factors was observed in all experiments, involving five different donor-recipient combinations. The number of converted recipients varied, depending upon the donor-recipient combination, but in all cases it was restricted by limiting numbers of either recipient or donor strains in the digestive tract of the microbially defined mice. Converted recipients were detected in fecal material as early as 5.5 hr after mice were associated with donor and recipient bacteria. Donors, recipients, and converted recipients were detectable in the stomach, small intestine, cecum, and large intestine of the microbially defined mice and their suckling young.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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