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. 1969 Oct;100(1):220–223. doi: 10.1128/jb.100.1.220-223.1969

Effect of Bile Acids on the Intestinal Absorption of Endotoxin in Rats

L T Kocsár 1, L Bertók 1, V Várterész 1
PMCID: PMC315381  PMID: 4898987

Abstract

The absorption of tritium-labeled Escherichia coli O89 Westphal-type endotoxin from the peritoneal cavity of rats was diminished by bile by 23% and by sodium deoxycholate by 47%, respectively. Practically, there is no endotoxin absorption from the intestinal tract of normal rats. The bile duct of rats was chronically cannulated for experimental purposes. A significant amount of perorally administered endotoxin absorbed from the intestinal canal into the blood in the rats treated thus. Absorption was demonstrated by the lethal effect of endotoxin on rats previously hypersensitized by lead acetate, and by the radioactivities found in the blood samples. The intestinal absorption of endotoxin in rats, rendered bile-deficient, may be prevented by sodium deoxycholate. Supported by their experimental findings, we emphasize the important role of bile acids in the defense mechanism of the macroorganism against bacterial endotoxins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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