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. 1965 Jan;89(1):41–46. doi: 10.1128/jb.89.1.41-46.1965

Photodynamic Inactivation of Enteroviruses

Craig Wallis 1, Joseph L Melnick 1
PMCID: PMC315545  PMID: 14255679

Abstract

Wallis, Craig (Baylor University College of Medicine, Houston, Tex.), and Joseph L. Melnick. Photodynamic inactivation of enteroviruses. J. Bacteriol. 89:41–46. 1965.—Enteroviruses are usually resistant to photodynamic inactivation, but they can be rendered completely photosensitive to proflavine at pH 9 to 10, if they are first purified by filtration through an anion resin. In addition, if enteroviruses are grown in cells maintained in a salt-glucose medium, they can be photosensitized. Of 38 enteroviruses tested, 10 were rendered completely photosensitive to proflavine, or toluidine blue, or both, and the remaining 28 viruses were sensitized, but to a lesser degree. The binding of dye to the virus can be reversed by lowering the pH.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. HIATT C. W., KAUFMAN E., HELPRIN J. J., BARON S. Inactivation of viruses by the photodynamic action of toluidine blue. J Immunol. 1960 May;84:480–484. [PubMed] [Google Scholar]
  2. HIATT C. W. Photodynamic inactivation of viruses. Trans N Y Acad Sci. 1960 Nov;23:66–78. doi: 10.1111/j.2164-0947.1960.tb01347.x. [DOI] [PubMed] [Google Scholar]
  3. WALLIS C., MELNICK J. L., BIANCHI M. Factors influencing enterovirus and reovirus growth and plaque formation. Tex Rep Biol Med. 1962;20:693–702. [PubMed] [Google Scholar]
  4. WALLIS C., MELNICK J. L. IRREVERSIBLE PHOTOSENSITIZATION OF VIRUSES. Virology. 1964 Aug;23:520–527. doi: 10.1016/0042-6822(64)90236-3. [DOI] [PubMed] [Google Scholar]
  5. WALLIS C., MELNICK J. L. Magnesium chloride enhancement of cell susceptibility to poliovirus. Virology. 1962 Feb;16:122–132. doi: 10.1016/0042-6822(62)90287-8. [DOI] [PubMed] [Google Scholar]
  6. WALLIS C., MELNICK J. L. PHOTODYNAMIC INACTIVATION OF POLIOVIRUS. Virology. 1963 Nov;21:332–341. doi: 10.1016/0042-6822(63)90194-6. [DOI] [PubMed] [Google Scholar]
  7. WALLIS C., MELNICK J. L. Suppression of adventitious agents in monkey kidney cultures. Tex Rep Biol Med. 1962;20:465–475. [PubMed] [Google Scholar]

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