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. 1965 Dec;90(6):1520–1524. doi: 10.1128/jb.90.6.1520-1524.1965

Mouse C-Reactive Protein and Endotoxin-Induced Resistance

L T Patterson a,1, R D Higginbotham a
PMCID: PMC315853  PMID: 5322718

Abstract

Patterson, L. T. (University of Texas, Galveston), and R. D. Higginbotham. Mouse C-reactive protein and endotoxin-induced resistance. J. Bacteriol. 90:1520–1524. 1965.—The relationship between the level of C-reactive protein (CRP) in the sera of mice and resistance to Staphylococcus aureus infection after the injection of Escherichia coli endotoxin was studied. The CRP level was essentially unchanged at 6 hr after endotoxin, and resistance was slightly decreased. At 24 hr after endotoxin, both CRP levels and resistance were increased. Since the increase in the CRP level and resistance appeared to be associated, it was of interest that, when mouse CRP was tested for in vitro reactions with several strains of bacteria, cells of all species of gram-positive bacteria tested (including S. aureus) were agglutinated by CRP. E. coli was not agglutinated under the conditions of the test. It is proposed that mouse CRP is an opsonin, and possibly a lysin, and is involved in nonspecific resistance to infection with S. aureus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON H. C., McCARTY M. The occurrence in the rabbit of an acute phase protein analogous to human C reactive protein. J Exp Med. 1951 Jan;93(1):25–36. doi: 10.1084/jem.93.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BIOZZI G., BENACERRAF B., HALPERN B. N. The effect of Salm. typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice. Br J Exp Pathol. 1955 Jun;36(3):226–235. [PMC free article] [PubMed] [Google Scholar]
  3. GOOD R. A., BRIDGES R. A., CONDIE R. M. Host-parasite relationships in patients with dysproteinemias. Bacteriol Rev. 1960 Mar;24(1):115–132. doi: 10.1128/br.24.1.115-132.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HEDLUND P. Clinical and experimental studies on C-reactive protein (acute phase protein). Acta Med Scand Suppl. 1961;361:1–71. [PubMed] [Google Scholar]
  5. HIGGINBOTHAM R. D., BASS J. A. ENDOTOXIC PROPERTIES OF AN EXTRACT OF S. AUREUS. Proc Soc Exp Biol Med. 1964 May;116:26–30. doi: 10.3181/00379727-116-29148. [DOI] [PubMed] [Google Scholar]
  6. HIGGINBOTHAM R. D., DOUGHERTY T. F. Mechanism of protective effect of hydrocortisone in staphylococci infected adrenalectomized mice. Proc Soc Exp Biol Med. 1955 Oct;90(1):253–258. doi: 10.3181/00379727-90-21999. [DOI] [PubMed] [Google Scholar]
  7. HOKAMA Y., COLEMAN M. K., RILEY R. F. Effect of drugs on Cx-protein responses in the rabbit. Proc Soc Exp Biol Med. 1960 Dec;105:510–514. doi: 10.3181/00379727-105-26160. [DOI] [PubMed] [Google Scholar]
  8. HOKAMA Y., COLEMAN M. K., RILEY R. F. In vitro effects of C-reactive protein on phagocytosis. J Bacteriol. 1962 May;83:1017–1024. doi: 10.1128/jb.83.5.1017-1024.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. JACOX R. F. The activation effect of calcium on a bactericidal substance for Bacillus subtilis in human serum. J Exp Med. 1950 Aug;92(2):101–111. doi: 10.1084/jem.92.2.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. OROSZLAN S. I., MORA P. T., SHEAR M. J. REVERSIBLE INACTIVATION OF AN ENDOTOXIN BY INTRACELLULAR PROTEIN. Biochem Pharmacol. 1963 Oct;12:1131–1146. doi: 10.1016/0006-2952(63)90087-x. [DOI] [PubMed] [Google Scholar]
  11. PATTERSON L. T., MORA E. C. OCCURRENCE OF A SUBSTANCE ANALOGOUS TO C-REACTIVE PROTEIN IN THE BLOOD OF THE DOMESTIC FOWL. Tex Rep Biol Med. 1964;22:716–721. [PubMed] [Google Scholar]
  12. Patterson L. T., Mora E. C. The C-reactive protein response and disease resistance in the domestic fowl. Tex Rep Biol Med. 1965 Fall;23(3):600–606. [PubMed] [Google Scholar]
  13. SHILO M., WOLMAN B. Activities of bacterial levans and of lipopolysaccharides in the processes of inflammation and infection. Br J Exp Pathol. 1958 Dec;39(6):652–660. [PMC free article] [PubMed] [Google Scholar]
  14. SUTER E., RAMSEIAR H. CELLULAR REACTIONS IN INFECTION. Adv Immunol. 1964;27:117–173. doi: 10.1016/s0065-2776(08)60707-5. [DOI] [PubMed] [Google Scholar]
  15. Springer G. F., Steers E., Dhanamitta S., Stinnett J., Gyorgy P. Protection of Mice against Lethal Staphylococcus Infection by Escherichia coli O86 Fractions. Science. 1961 Aug 4;134(3475):335–336. doi: 10.1126/science.134.3475.335. [DOI] [PubMed] [Google Scholar]
  16. WHITBY J. L., MICHAEL J. G., WOODS M. W., LANDY M. Symposium on bacterial endotoxins. II. Possible mechanisms whereby endotoxins evoke increased nonspecific resistance to infection. Bacteriol Rev. 1961 Dec;25:437–446. doi: 10.1128/br.25.4.437-446.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. WOOD H. F. Effect of C-reactive protein on normal human leukocytes. Proc Soc Exp Biol Med. 1951 Apr;76(4):843–847. doi: 10.3181/00379727-76-18650. [DOI] [PubMed] [Google Scholar]
  18. WOOD H. F. The relationship between the acute phase response and antibody production in the rabbit. I. Correlation between the early appearance of Cx-reaction protein and subsequent antibody production. J Exp Med. 1953 Oct;98(4):311–319. doi: 10.1084/jem.98.4.311. [DOI] [PMC free article] [PubMed] [Google Scholar]

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