Skip to main content
PMC home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1966 Apr;91(4):1494–1508. doi: 10.1128/jb.91.4.1494-1508.1966

Distribution and Function of Genes Concerned with Aromatic Biosynthesis in Escherichia coli

James Pittard 1, B J Wallace 1
PMCID: PMC316068  PMID: 5326114

Abstract

Pittard, James (School of Microbiology, University of Melbourne, Victoria, Australia), and B. J. Wallace. Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli. J. Bacteriol. 91:1494–1508. 1966.—A number of mutant strains of Escherichia coli K-12, which are blocked in the biosynthesis of the aromatic amino acids, were examined biochemically to determine their particular enzymatic deficiencies. The mutations carried by these strains were mapped by use of the methods of conjugation and transduction. Structural genes for five of the enzymes of the common pathway leading to chorismate and for the two enzymes converting chorismate to phenylpyruvate and p-hydroxyphenylpyruvate, respectively, were identified. Unlike the genes of the tryptophan operon most of these genes are distributed over widely separated regions of the chromosome.

Full text

PDF
1508

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADELBERG E. A., BURNS S. N. Genetic variation in the sex factor of Escherichia coli. J Bacteriol. 1960 Mar;79:321–330. doi: 10.1128/jb.79.3.321-330.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. ADELBERG E. A., MYERS J. W. Modification of the penicillin technique for the selection of auxotrophic bacteria. J Bacteriol. 1953 Mar;65(3):348–353. doi: 10.1128/jb.65.3.348-353.1953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BROWN K. D., DOY C. H. END-PRODUCT REGULATION OF THE GENERAL AROMATIC-PATHWAY IN ESCHERICHIA COLI W. Biochim Biophys Acta. 1963 Sep 3;77:170–172. doi: 10.1016/0006-3002(63)90489-x. [DOI] [PubMed] [Google Scholar]
  4. COTTON R. G., GIBSON F. THE BIOSYNTHESIS OF PHENYLALANINE AND TYROSINE; ENZYMES CONVERTING CHORISMIC ACID INTO PREPHENIC ACID AND THEIR RELATIONSHIPS TO PREPHENATE DEHYDRATASE AND PREPHENATE DEHYDROGENASE. Biochim Biophys Acta. 1965 Apr 12;100:76–88. doi: 10.1016/0304-4165(65)90429-0. [DOI] [PubMed] [Google Scholar]
  5. COX G. B., GIBSON F. BIOSYNTHESIS OF VITAMIN K AND UBIQUINONE. RELATION TO THE SHIKIMIC ACID PATHWAY IN ESCHERICHIA COLI. Biochim Biophys Acta. 1964 Oct 9;93:204–206. doi: 10.1016/0304-4165(64)90285-5. [DOI] [PubMed] [Google Scholar]
  6. DAVIS B. D. Aromatic biosynthesis. V. Antagonism between shikimic acid and its precursor, 5-dehydroshikimic acid. J Bacteriol. 1952 Nov;64(5):749–763. doi: 10.1128/jb.64.5.749-763.1952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GAITONDE M. K., GORDON M. W. A microchemical method for the detection and determination of shikimic acid. J Biol Chem. 1958 Feb;230(2):1043–1050. [PubMed] [Google Scholar]
  8. GIBSON F., GIBSON M., COX G. B. THE BIOSYNTHESIS OF P-AMINOBENZOIC ACID FROM CHORISMIC ACID. Biochim Biophys Acta. 1964 Mar 16;82:637–638. doi: 10.1016/0304-4165(64)90465-9. [DOI] [PubMed] [Google Scholar]
  9. Gibson F. Chorismic acid: purification and some chemical and physical studies. Biochem J. 1964 Feb;90(2):256–261. doi: 10.1042/bj0900256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gibson M. I., Gibson F. Preliminary studies on the isolation and metabolism of an intermediate in aromatic biosynthesis: chorismic acid. Biochem J. 1964 Feb;90(2):248–256. doi: 10.1042/bj0900248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LOPER J. C., GRABNAR M., STAHL R. C., HARTMAN Z., HARTMAN P. E. GENES AND PROTEINS INVOLVED IN HISTIDINE BIOSYNTHESIS IN SALMONELLA. Brookhaven Symp Biol. 1964 Dec;17:15–52. [PubMed] [Google Scholar]
  12. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  13. Lim P. G., Mateles R. I. Tryptophan- and indole-excreting prototrophic mutant of Escherichia coli. J Bacteriol. 1964 May;87(5):1051–1055. doi: 10.1128/jb.87.5.1051-1055.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. MITSUHASHI S., DAVIS B. D. Aromatic biosynthesis. XII. Conversion of 5-dehydroquinic acid to 5-dehydroshikimic acid dy 5-dehydroquinase. Biochim Biophys Acta. 1954 Sep;15(1):54–61. doi: 10.1016/0006-3002(54)90093-1. [DOI] [PubMed] [Google Scholar]
  15. MORGAN P. N., GIBSON M. I., GIBSON F. THE CONVERSION OF SHIKIMIC ACID INTO CERTAIN AROMATIC COMPOUNDS BY CELL-FREE EXTRACTS OF AEROBACTER AEROGENES AND ESCHERICHIA COLI. Biochem J. 1963 Nov;89:229–239. doi: 10.1042/bj0890229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SANDERSON K. E., DEMEREC M. THE LINKAGE MAP OF SALMONELLA TYPHIMURIUM. Genetics. 1965 Jun;51:897–913. doi: 10.1093/genetics/51.6.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. SMITH L. C., RAVEL J. M., LAX S. R., SHIVE W. The control of 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthesis by phenylalanine and tyrosine. J Biol Chem. 1962 Nov;237:3566–3570. [PubMed] [Google Scholar]
  18. SRINIVASAN P. R., SPRINSON D. B. 2-Keto-3-deoxy-D-arabo-heptonic acid 7-phosphate synthetase. J Biol Chem. 1959 Apr;234(4):716–722. [PubMed] [Google Scholar]
  19. TAYLOR A. L., THOMAN M. S. THE GENETIC MAP OF ESCHERICHIA COLI K-12. Genetics. 1964 Oct;50:659–677. doi: 10.1093/genetics/50.4.659. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. YANIV H., GILVARG C. Aromatic biosynthesis. XIV. 5-Dehydroshikimic reductase. J Biol Chem. 1955 Apr;213(2):787–795. [PubMed] [Google Scholar]
  21. Yanofsky C., Crawford I. P. THE EFFECTS OF DELETIONS, POINT MUTATIONS, REVERSIONS AND SUPPRESSOR MUTATIONS ON THE TWO COMPONENTS OF THE TRYPTOPHAN SYNTHETASE OF ESCHERICHIA COLI. Proc Natl Acad Sci U S A. 1959 Jul;45(7):1016–1026. doi: 10.1073/pnas.45.7.1016. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES