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. 1981 Feb;78(2):1129–1132. doi: 10.1073/pnas.78.2.1129

Some calculations on the amount of selfish DNA.

T Ohta, M Kimura
PMCID: PMC319960  PMID: 6940131

Abstract

A population genetical theory is developed to treat the amount of selfish DNA in a genome. We assume that the selfish DNA consists of replicating units and that it evolves by multiplication within a genome, exchange between genomes, and random genetic drift at reproduction. Special reference is made to the mean and variance of the number of replicating units per genome in the population. Under the assumption of no systematic evolutionary pressure, the number of units changes randomly with time, and its variance increases by replication process. Although under certain circumstances the variance increases also by exchange process, under ordinary circumstances this process tends to decrease the variance. Random genetic drift also reduces the variance. The relationship between the mean and variance at equilibrium of the number of replicating units per genome in the population was derived. The results obtained will be useful in understanding various observations on repeated DNA which presumably does not contain genetic information and which is likely to be selectively neutral.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Calos M. P., Miller J. H. Transposable elements. Cell. 1980 Jul;20(3):579–595. doi: 10.1016/0092-8674(80)90305-0. [DOI] [PubMed] [Google Scholar]
  2. Cameron J. R., Loh E. Y., Davis R. W. Evidence for transposition of dispersed repetitive DNA families in yeast. Cell. 1979 Apr;16(4):739–751. doi: 10.1016/0092-8674(79)90090-4. [DOI] [PubMed] [Google Scholar]
  3. Crow J. F. Genes that violate Mendel's rules. Sci Am. 1979 Feb;240(2):134-43, 146. doi: 10.1038/scientificamerican0279-134. [DOI] [PubMed] [Google Scholar]
  4. Doolittle W. F., Sapienza C. Selfish genes, the phenotype paradigm and genome evolution. Nature. 1980 Apr 17;284(5757):601–603. doi: 10.1038/284601a0. [DOI] [PubMed] [Google Scholar]
  5. Fedoroff N. V. On spacers. Cell. 1979 Apr;16(4):697–710. doi: 10.1016/0092-8674(79)90086-2. [DOI] [PubMed] [Google Scholar]
  6. Finnegan D. J., Rubin G. M., Young M. W., Hogness D. S. Repeated gene families in Drosophila melanogaster. Cold Spring Harb Symp Quant Biol. 1978;42(Pt 2):1053–1063. doi: 10.1101/sqb.1978.042.01.106. [DOI] [PubMed] [Google Scholar]
  7. Hood J. M., Huang H. V., Hood L. A computer simulation of evolutionary forces controlling the size of a multigene family. J Mol Evol. 1980 Jul;15(3):181–196. doi: 10.1007/BF01732947. [DOI] [PubMed] [Google Scholar]
  8. Hood L., Campbell J. H., Elgin S. C. The organization, expression, and evolution of antibody genes and other multigene families. Annu Rev Genet. 1975;9:305–353. doi: 10.1146/annurev.ge.09.120175.001513. [DOI] [PubMed] [Google Scholar]
  9. Ilyin Y. V., Tchurikov N. A., Ananiev E. V., Ryskov A. P., Yenikolopov G. N., Limborska S. A., Maleeva N. E., Gvozdev V. A., Georgiev G. P. Studies on the DNA fragments of mammals and Drosophila containing structural genes and adjacent sequences. Cold Spring Harb Symp Quant Biol. 1978;42(Pt 2):959–969. doi: 10.1101/sqb.1978.042.01.097. [DOI] [PubMed] [Google Scholar]
  10. KIMURA M., CROW J. F. THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION. Genetics. 1964 Apr;49:725–738. doi: 10.1093/genetics/49.4.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KIMURA M., KAYANO H. The maintenance of super-numerary chromosomes in wild populations of Lilium callosum by preferential segregation. Genetics. 1961 Dec;46:1699–1712. doi: 10.1093/genetics/46.12.1699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nishioka Y., Leder A., Leder P. Unusual alpha-globin-like gene that has cleanly lost both globin intervening sequences. Proc Natl Acad Sci U S A. 1980 May;77(5):2806–2809. doi: 10.1073/pnas.77.5.2806. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Orgel L. E., Crick F. H. Selfish DNA: the ultimate parasite. Nature. 1980 Apr 17;284(5757):604–607. doi: 10.1038/284604a0. [DOI] [PubMed] [Google Scholar]
  14. Smith G. P. Unequal crossover and the evolution of multigene families. Cold Spring Harb Symp Quant Biol. 1974;38:507–513. doi: 10.1101/sqb.1974.038.01.055. [DOI] [PubMed] [Google Scholar]
  15. Sprague K. U., Roth M. B., Manning R. F., Gage L. P. Alleles of the fibroin gene coding for proteins of different lengths. Cell. 1979 Jun;17(2):407–413. doi: 10.1016/0092-8674(79)90167-3. [DOI] [PubMed] [Google Scholar]
  16. Vanin E. F., Goldberg G. I., Tucker P. W., Smithies O. A mouse alpha-globin-related pseudogene lacking intervening sequences. Nature. 1980 Jul 17;286(5770):222–226. doi: 10.1038/286222a0. [DOI] [PubMed] [Google Scholar]
  17. Yamamoto M., Miklos G. L. Genetic studies on heterochromatin in Drosophila melanogaster and their implications for the functions of satellite DNA. Chromosoma. 1978 Mar 22;66(1):71–98. doi: 10.1007/BF00285817. [DOI] [PubMed] [Google Scholar]
  18. Young M. W. Middle repetitive DNA: a fluid component of the Drosophila genome. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6274–6278. doi: 10.1073/pnas.76.12.6274. [DOI] [PMC free article] [PubMed] [Google Scholar]

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