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. 1981 Aug;78(8):5014–5015. doi: 10.1073/pnas.78.8.5014

Are viroids escaped introns?

T O Diener 1
PMCID: PMC320322  PMID: 16593072

Abstract

A complex of considerable stability is possible between the 5′ end of U1 RNA and a specific nucleotide sequence of the potato spindle tuber viroid complement. Because base-pairing between the 5′ end of U1 RNA and the ends of introns is believed by some to be responsible for the precise alignment and correct excision of introns, the U1-related sequence may represent the two ends of a presumed intron ancestor of the viroid complement after circularization.

Keywords: split genes, RNA splicing, small nuclear RNAs, U1 RNA

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avvedimento V. E., Vogeli G., Yamada Y., Maizel J. V., Jr, Pastan I., de Crombrugghe B. Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA. Cell. 1980 Oct;21(3):689–696. doi: 10.1016/0092-8674(80)90432-8. [DOI] [PubMed] [Google Scholar]
  2. Borst P., Grivell L. A. One gene's intron is another gene's exon. Nature. 1981 Feb 5;289(5797):439–440. doi: 10.1038/289439a0. [DOI] [PubMed] [Google Scholar]
  3. Crick F. Split genes and RNA splicing. Science. 1979 Apr 20;204(4390):264–271. doi: 10.1126/science.373120. [DOI] [PubMed] [Google Scholar]
  4. Davies J. W., Kaesberg P., Diener T. O. Potato spindle tuber viroid. XII. An investigation of viroid RNA as a messenger for protein synthesis. Virology. 1974 Sep;61(1):281–286. doi: 10.1016/0042-6822(74)90262-1. [DOI] [PubMed] [Google Scholar]
  5. Diener T. O. Viroids: structure and function. Science. 1979 Aug 31;205(4409):859–866. doi: 10.1126/science.472709. [DOI] [PubMed] [Google Scholar]
  6. Grill L. K., Semancik J. S. RNA sequences complementary to citrus exocortis viroid in nucleic acid preparations from infected Gynura aurantiaca. Proc Natl Acad Sci U S A. 1978 Feb;75(2):896–900. doi: 10.1073/pnas.75.2.896. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gross H. J., Domdey H., Lossow C., Jank P., Raba M., Alberty H., Sänger H. L. Nucleotide sequence and secondary structure of potato spindle tuber viroid. Nature. 1978 May 18;273(5659):203–208. doi: 10.1038/273203a0. [DOI] [PubMed] [Google Scholar]
  8. Gross H. J., Riesner D. Viroids: a class of subviral pathogens. Angew Chem Int Ed Engl. 1980;19(4):231–243. doi: 10.1002/anie.198002313. [DOI] [PubMed] [Google Scholar]
  9. Hadidi A., Jones D. M., Gillespie D. H., Wong-Staal F., Diener T. O. Hybridization of potato spindle tuber viroid to cellular DNA of normal plants. Proc Natl Acad Sci U S A. 1976 Jul;73(7):2453–2457. doi: 10.1073/pnas.73.7.2453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Halbreich A., Pajot P., Foucher M., Grandchamp C., Slonimski P. A pathway of cytochrome b mRNA processing in yeast mitochondria: specific splicing steps and an intron-derived circular DNA. Cell. 1980 Feb;19(2):321–329. doi: 10.1016/0092-8674(80)90506-1. [DOI] [PubMed] [Google Scholar]
  11. Lerner M. R., Boyle J. A., Mount S. M., Wolin S. L., Steitz J. A. Are snRNPs involved in splicing? Nature. 1980 Jan 10;283(5743):220–224. doi: 10.1038/283220a0. [DOI] [PubMed] [Google Scholar]
  12. Murray V., Holliday R. Mechanism for RNA splicing of gene transcripts. FEBS Lett. 1979 Oct 1;106(1):5–7. doi: 10.1016/0014-5793(79)80682-1. [DOI] [PubMed] [Google Scholar]
  13. Owens R. A., Cress D. E. Molecular cloning and characterization of potato spindle tuber viroid cDNA sequences. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5302–5306. doi: 10.1073/pnas.77.9.5302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Reddy R., Ro-Choi T. S., Henning D., Busch H. Primary sequence of U-1 nuclear ribonucleic acid of Novikoff hepatoma ascites cells. J Biol Chem. 1974 Oct 25;249(20):6486–6494. [PubMed] [Google Scholar]
  15. Rogers J., Wall R. A mechanism for RNA splicing. Proc Natl Acad Sci U S A. 1980 Apr;77(4):1877–1879. doi: 10.1073/pnas.77.4.1877. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Tinoco I., Jr, Borer P. N., Dengler B., Levin M. D., Uhlenbeck O. C., Crothers D. M., Bralla J. Improved estimation of secondary structure in ribonucleic acids. Nat New Biol. 1973 Nov 14;246(150):40–41. doi: 10.1038/newbio246040a0. [DOI] [PubMed] [Google Scholar]

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