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. 1982 Mar 11;10(5):1707–1720. doi: 10.1093/nar/10.5.1707

Recognition of base pairs by polar peptides in double stranded DNA.

A Laigle, L Chinsky, P Y Turpin
PMCID: PMC320560  PMID: 7071020

Abstract

The resonance Raman spectrum of native DNA has been obtained using excitation at 257 nm. In a first part, the spectral lines are assigned to the different nucleotide bases which provide the resonance effect. In a second part, the interactions of DNA with basic peptides (Arginine Methylester, Lysine Methylester, Arginyl-Arginine) are investigated using excitation at 300 nm and 257 nm, which give complementary information about the DNA. Both Arginine Methylester and Arginyl-arginine recognize the A-T base pairs, the first one in the large groove, the second one in the narrow groove of DNA. The DNA-Lysine Methylester interaction is very likely not specific but can take place in the large groove of DNA.

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Selected References

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