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. 1982 Aug 25;10(16):4873–4882. doi: 10.1093/nar/10.16.4873

Isolation of the human HDL apoprotein A1 gene.

C C Shoulders, F E Baralle
PMCID: PMC320834  PMID: 6290991

Abstract

Apo A1 is the major apoprotein of the human plasma high density lipoprotein (HDL). We have isolated apo A1 cDNA and genomic clones and used them to study the gene organisation as defined by its restriction enzyme map. These studies showed that apo A1 is coded by a unique gene. Cross hybridisation was not observed with functionally related apoprotein genes. Increased levels of HDL have been correlated with certain protection against coronary heart disease. If there is a genetic component that contributes to the variable levels of HDL found in the population, it may be possible to correlate these differences with distinct gene organisation patterns.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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