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. 1985 Sep 25;13(18):6651–6661. doi: 10.1093/nar/13.18.6651

Sequence of the D beta 2-J beta 2 region of the human T-cell receptor beta-chain locus.

A Tunnacliffe, T H Rabbitts
PMCID: PMC321983  PMID: 2997718

Abstract

We have sequenced the region encompassing a D beta 2 segment and the J beta 2 segments of the human T-cell antigen receptor beta-chain genes. The D beta 2 element lies about 650 base pairs upstream of a cluster of seven potentially functional J beta 2 sequences and one J beta 2 pseudogene. Examination of human beta-chain cDNA sequences which involve rearranged D beta 2 and J beta 2 elements demonstrates that N-region, as well as junctional, diversity can occur during D-J joining. Further, we present evidence for possible somatic mutation in active J beta 2 segments.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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