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. 1969 Jun;48(6):1002–1006. doi: 10.1172/JCI106056

Mechanism of change in the excretion of sodium per nephron when renal mass is reduced

John P Hayslett 1,2, Michael Kashgarian 1,2, Franklin H Epstein 1,2
PMCID: PMC322314  PMID: 5771184

Abstract

As the population of nephrons is reduced, sodium excretion per nephron must increase if sodium balance is to be maintained. The mechanism of this adjustment was studied in rats in which 50% and approximately 85% of renal tissue was excised. Although glomerular filtration per remaining nephron rose after uninephrectomy, it did not rise further when more renal tissue was removed, even though sodium excretion per nephron mounted. Hyperfiltration does not, therefore, account for the stepwise increase in sodium excretion per nephron with progressive renal ablation. Proximal tubular absorption, estimated by reabsorption half-time, was unchanged by renal insufficiency, indicating that “third factor” did not produce the observed changes in sodium excretion per nephron. It seems likely that the earliest adjustments in sodium excretion in renal failure take place in the distal tubules of healthy nephrons, and that they are conditioned by changes in the osmotic load per nephron.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIBER T. U., MYLLE M., LASSITER W. E., GOTTSCHALK C. W. MICROPUNCTURE STUDY OF WATER REABSORPTION AND PAH SECRETION IN UREA DIURESIS IN RATS. Proc Soc Exp Biol Med. 1965 Jul;119:871–876. doi: 10.3181/00379727-119-30324. [DOI] [PubMed] [Google Scholar]
  2. BRICKER N. S., KLAHR S., RIESELBACH R. E. THE FUNCTIONAL ADAPTATION OF THE DISEASED KIDNEY. I. GLOMERULAR FILTRATION RATE. J Clin Invest. 1964 Oct;43:1915–1921. doi: 10.1172/JCI105065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bank N., Aynedjian H. S. Individual nephron function in experimental bilateral pyelonephritis. I. Glomerular filtration rate and proximal tubular sodium, potassium, and water reabsorption. J Lab Clin Med. 1966 Nov;68(5):713–727. [PubMed] [Google Scholar]
  4. Bank N., Aynedjian H. S. Individual nephron function in experimental bilateral pyelonephritis. II. Distal tubular sodium and water reabsorption and the concentrating defect. J Lab Clin Med. 1966 Nov;68(5):728–739. [PubMed] [Google Scholar]
  5. COPE C. L., PEARSON J. ALDOSTERONE SECRETION IN SEVERE RENAL FAILURE. Clin Sci. 1963 Oct;25:331–341. [PubMed] [Google Scholar]
  6. Carrasquer G., Solomon S., Sonnenberg H. Evidence of restricted permeability to urea in rat distal tubule. Proc Soc Exp Biol Med. 1967 Jul;125(3):828–832. doi: 10.3181/00379727-125-32216. [DOI] [PubMed] [Google Scholar]
  7. GERTZ K. H. [Transtubular sodium chloride transport and permeability for nonelectrolytes in the proximal and distal convolution of the rat kidney]. Pflugers Arch Gesamte Physiol Menschen Tiere. 1963;276:336–356. [PubMed] [Google Scholar]
  8. GONICK H. C., COBURN J. W., RUBINI M. E., MAXWELL M. H., KLEEMAN C. R. STUDIES OF EXPERIMENTAL RENAL FAILURE IN DOGS. II. EFFECT OF FIVE-SIXTHS NEPHRECTOMY ON SODIUM-CONSERVING ABILITY OF RESIDUAL NEPHRONS. J Lab Clin Med. 1964 Aug;64:269–276. [PubMed] [Google Scholar]
  9. Hayslett J. P., Kashgarian M., Epstein F. H. Changes in proximal and distal tubular reabsorption produced by rapid expansion of extracellular fluid. J Clin Invest. 1967 Jul;46(7):1254–1263. doi: 10.1172/JCI105618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hayslett J. P., Kashgarian M., Epstein F. H. Functional correlates of compensatory renal hypertrophy. J Clin Invest. 1968 Apr;47(4):774–799. doi: 10.1172/JCI105772. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lubowitz H., Purkerson M. L., Bricker N. S. Investigation of single nephrons in the chronically diseased (Pyelonephritic) kidney of the rat using micropuncture techniques. Nephron. 1966;3(2):73–83. doi: 10.1159/000179449. [DOI] [PubMed] [Google Scholar]
  12. Morrison A. B., Howard R. M. The functional capacity of hypertrophied nephrons. Effect of partial nephrectomy on the clearance of inulin and PAH in the rat. J Exp Med. 1966 May 1;123(5):829–844. doi: 10.1084/jem.123.5.829. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. PLATT R. Structural and functional adaptation in renal failure. Br Med J. 1952 Jun 28;1(4773):1372–concl. doi: 10.1136/bmj.1.4773.1372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Platts M. M. Electrolyte excretion in uraemia. Clin Sci. 1966 Jun;30(3):453–471. [PubMed] [Google Scholar]
  15. Schultze R. G., Slatopolsky E., Tall B., Walker W., Levy M., Bricker N. S. The regulation of sodium excretion in uremia: a new dimension in the characterization of "third factor". Trans Assoc Am Physicians. 1966;79:322–329. [PubMed] [Google Scholar]
  16. WIRZ H. Der osmotische Druck in den corticalen Tubuli der Rattenniere. Helv Physiol Pharmacol Acta. 1956;14(3):353–362. [PubMed] [Google Scholar]
  17. Winghager E. E. Glomerulo-tubular balance of sale and water. Physiologist. 1968 May;11(2):103–114. [PubMed] [Google Scholar]

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