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. 1969 Aug;48(8):1489–1494. doi: 10.1172/JCI106115

An enzymatic basis for Lewis blood Types in man

Evelyn F Grollman 1, Akira Kobata 1, Victor Ginsburg 1
PMCID: PMC322376  PMID: 5796361

Abstract

Milk from women with blood type Le(a+) or Le(b+) contains a specific fucosyltransferase not found in the milk of women with blood type Le(a- b-). The enzyme, a guanosine diphosphate L-fucose: N-acetyl-β-D-glucosaminylsaccharide α-4-L-fucosyltransferase is apparently required for the synthesis of the structural determinants of Lea and Leb specificity, both of which contain fucose in an α-1,4 linkage to N-acetylglucosamine. The same enzyme is also involved in the synthesis of milk oligosaccharides, as two oligosaccharides which contain this linkage are absent from the milk of women with Le(a- b-) blood type.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDRESEN P. H. Relations between the ABO, secretor/nonsecretor, and Lewis systems with particular reference to the Lewis system. Am J Hum Genet. 1961 Dec;13:396–412. [PMC free article] [PubMed] [Google Scholar]
  2. Babad H., Hassid W. Z. Soluble uridine diphosphate D-galactose: D-glucose beta-4-D-galactosyltransferase from bovine milk. J Biol Chem. 1966 Jun 10;241(11):2672–2678. [PubMed] [Google Scholar]
  3. Elson L. A., Morgan W. T. A colorimetric method for the determination of glucosamine and chondrosamine. Biochem J. 1933;27(6):1824–1828. doi: 10.1042/bj0271824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Grollman E. F., Ginsburg V. Correlation between secretor status and the occurrence of 2'-fucosyllactose in human milk. Biochem Biophys Res Commun. 1967 Jul 10;28(1):50–53. doi: 10.1016/0006-291x(67)90404-4. [DOI] [PubMed] [Google Scholar]
  5. KUHN R. Les oligosaccharides du lait. Bull Soc Chim Biol (Paris) 1958;40(2-3):297–314. [PubMed] [Google Scholar]
  6. Kobata A., Ginsburg V., Tsuda M. Oligosaccharides of human milk. I. Isolation and characterization. Arch Biochem Biophys. 1969 Mar;130(1):509–513. doi: 10.1016/0003-9861(69)90063-0. [DOI] [PubMed] [Google Scholar]
  7. Kobata A., Grollman E. F., Ginsburg V. An enzymatic basis for blood type B in humans. Biochem Biophys Res Commun. 1968 Jul 26;32(2):272–277. doi: 10.1016/0006-291x(68)90380-x. [DOI] [PubMed] [Google Scholar]
  8. Kobata A., Grollman E. F., Ginsburg V. An enzymic basis for blood type A in humans. Arch Biochem Biophys. 1968 Mar 20;124(1):609–612. doi: 10.1016/0003-9861(68)90373-1. [DOI] [PubMed] [Google Scholar]
  9. Lloyd K. O., Kabat E. A., Licerio E. [Immunochemical studies on blood groups. 38. Structures and activities of oligosaccharides produced by alkaline degradation of blood-group Lewis-a substance. Proposed structure of the carbohydrate chains of human blood-group A, B, H, Le-a, and Le-b substances]. Biochemistry. 1968 Aug;7(8):2976–2990. doi: 10.1021/bi00848a039. [DOI] [PubMed] [Google Scholar]
  10. MONTREUIL J. [The glucides of milk]. Bull Soc Chim Biol (Paris) 1960;42:1399–1427. [PubMed] [Google Scholar]
  11. Marcus D. M., Grollman A. P. Studies of blood group substances. I. Caprine precipitating antisera to human Le-a and Le-b blood group substances. J Immunol. 1966 Dec;97(6):867–875. [PubMed] [Google Scholar]
  12. Marr A. M., Donald A. S., Watkins W. M., Morgan W. T. Molecular and genetic aspects of human blood-group Le-b specificity. Nature. 1967 Sep 23;215(5108):1345–1349. doi: 10.1038/2151345a0. [DOI] [PubMed] [Google Scholar]
  13. REGE V. P., PAINTER T. J., WATKINS W. M., MORGAN W. T. ISOLATION OF A SEROLOGICALLY ACTIVE, FUCOSE-CONTAINING, TRISACCHARIDE FROM HUMAN BLOOD-GROUP LEA SUBSTANCE. Nature. 1964 Nov 21;204:740–742. doi: 10.1038/204740a0. [DOI] [PubMed] [Google Scholar]
  14. Race C., Ziderman D., Watkins W. M. An alpha-d-galactosyltransferase associated with the blood-group B character. Biochem J. 1968 May;107(5):733–735. doi: 10.1042/bj1070733. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Shen L., Grollman E. F., Ginsburg V. An enzymatic basis for secretor status and blood group substance specificity in humans. Proc Natl Acad Sci U S A. 1968 Jan;59(1):224–230. doi: 10.1073/pnas.59.1.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. WATKINS W. M., MORGAN W. T. Further observations on the inhibition of blood-group specific serological reactions by simple sugars of known structure. Vox Sang. 1962;7:129–150. doi: 10.1111/j.1423-0410.1962.tb03238.x. [DOI] [PubMed] [Google Scholar]
  17. WATKINS W. M., MORGAN W. T. Possible genetical pathways for the biosynthesis of blood group mucopolysaccharides. Vox Sang. 1959 Apr;4(2):97–119. doi: 10.1111/j.1423-0410.1959.tb04023.x. [DOI] [PubMed] [Google Scholar]

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