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. 1970 Feb;49(2):197–205. doi: 10.1172/JCI106228

Ferrokinetics: a biologic model for plasma iron exchange in man

J D Cook 1, G Marsaglia 1, J W Eschbach 1, D D Funk 1, C A Finch 1
PMCID: PMC322461  PMID: 5411779

Abstract

A method is presented for calculating internal iron kinetics. An early reflux associated with extravascular exchange and a late reflux associated with erythropoiesis are described. A biologic model of iron exchange is proposed in which erythron iron turnover is divided into an effective portion (iron fixed in circulating red cells) and wastage iron of erythropoiesis (late reflux). Nonerythroid iron exchange also has a fixed portion (parenchymal uptake) and an early reflux (lymphatic circuit), both of which correlate in amount with the amount of plasma iron. Ferrokinetic measurements in normal subjects and in various pathologic states are presented to validate the model.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BESSIS M. C., BRETON-GORIUS J. Ferrtin and ferruginous micelles in normal erythroblasts and hypochromic hypersideremic anemias. Blood. 1959 Apr;14(4):423–432. [PubMed] [Google Scholar]
  2. BOTHWELL T. H., MALLETT B. Diurnal variation in the turnover of iron through the plasma. Clin Sci. 1955 May;14(2):235–239. [PubMed] [Google Scholar]
  3. Barrett P. V., Cline M. J., Berlin N. I. The association of the urobilin "early peak" and erythropoiesis in man. J Clin Invest. 1966 Nov;45(11):1657–1667. doi: 10.1172/JCI105473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FINCH S. C., FINCH C. A. Idiopathic hemochromatosis, an iron storage disease. A. Iron metabolism in hemochromatosis. Medicine (Baltimore) 1955 Dec;34(4):381–430. doi: 10.1097/00005792-195512000-00001. [DOI] [PubMed] [Google Scholar]
  5. Green R., Charlton R., Seftel H., Bothwell T., Mayet F., Adams B., Finch C., Layrisse M. Body iron excretion in man: a collaborative study. Am J Med. 1968 Sep;45(3):336–353. doi: 10.1016/0002-9343(68)90069-7. [DOI] [PubMed] [Google Scholar]
  6. HOSAIN F., FINCH C. A. FERROKINETICS: A STUDY OF TRANSPORT IRON IN PLASMA. J Lab Clin Med. 1964 Dec;64:905–912. [PubMed] [Google Scholar]
  7. HUFF R. L., ELMLINGER P. J., GARCIA J. F., ODA J. M., COCKRELL M. C., LAWRENCE J. H. Ferrokinetics in normal persons and in patients having various erythropoietic disorders. J Clin Invest. 1951 Dec;30(122):1512–1526. doi: 10.1172/JCI102562. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HUFF R. L., HENNESSY T. G., AUSTIN R. E., GARCIA J. F., ROBERTS B. M., LAWRENCE J. H. Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders. J Clin Invest. 1950 Aug;29(8):1041–1052. doi: 10.1172/JCI102335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Harker L. A., Funk D. D., Finch C. A. Evaluation of storage iron by chelates. Am J Med. 1968 Jul;45(1):105–115. doi: 10.1016/0002-9343(68)90012-0. [DOI] [PubMed] [Google Scholar]
  10. Hosain F., Marsaglia G., Finch C. A. Blood ferrokinetics in normal man. J Clin Invest. 1967 Jan;46(1):1–9. doi: 10.1172/JCI105501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. JERNERUS R., LUNDIN G., PUGH L. G. SOLUBILITY OF ACETYLENE IN LUNG TISSUE AS AN ERROR IN CARDIAC OUTPUT DETERMINATION WITH THE ACETYLENE METHOD. Acta Physiol Scand. 1963 Sep-Oct;59:1–6. doi: 10.1111/j.1748-1716.1963.tb02717.x. [DOI] [PubMed] [Google Scholar]
  12. MORGAN E. H., CARTER G. Plasma iron and iron-binding capacity levels in health and disease: with an improved method for the estimation of plasma iron concentration and total iron-binding capacity. Australas Ann Med. 1960 Aug;9:209–213. doi: 10.1111/imj.1960.9.3.209. [DOI] [PubMed] [Google Scholar]
  13. Morgan E. H., Marsaglia G., Giblett E. R., Finch C. A. A method of investigating internal iron exchange utilizing two types of transferrin. J Lab Clin Med. 1967 Mar;69(3):370–381. [PubMed] [Google Scholar]
  14. NOYES W. D., HOSAIN F., FINCH C. A. INCORPORATION OF RADIOIRON INTO MARROW HEME. J Lab Clin Med. 1964 Oct;64:574–580. [PubMed] [Google Scholar]
  15. Najean Y., Dresch C., Ardaillou N., Bernard J. Iron metabolism--a study of different kinetic models in normal conditions. Am J Physiol. 1967 Aug;213(2):533–546. doi: 10.1152/ajplegacy.1967.213.2.533. [DOI] [PubMed] [Google Scholar]
  16. POLLYCOVE M., MORTIMER R. The quantitative determination of iron kinetics and hemoglobin synthesis in human subjects. J Clin Invest. 1961 May;40:753–782. doi: 10.1172/JCI104310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. SHARNEY L., SCHWARTZ L., WASSERMAN L. R., PORT S., LEAVITT D. Pool systems in iron metabolism; with special reference to polycythemia vera. Proc Soc Exp Biol Med. 1954 Nov;87(2):489–492. doi: 10.3181/00379727-87-21421. [DOI] [PubMed] [Google Scholar]
  18. SHARNEY L., WASSERMAN L. R., SCHWARTZ L., TENDLER D. Multiple pool analysis as applied to erythro-kinetics. Ann N Y Acad Sci. 1963 May 10;108:230–249. doi: 10.1111/j.1749-6632.1963.tb13377.x. [DOI] [PubMed] [Google Scholar]

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