Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1970 Jul;49(7):1316–1323. doi: 10.1172/JCI106347

Experimental myocardial infarction

IV. Reduction of left ventricular compliance in the healing phase

William B Hood Jr 1,2,3, Jesus A Bianco 1,2,3, Raj Kumar 1,2,3, Richard B Whiting 1,2,3
PMCID: PMC322603  PMID: 4914678

Abstract

Compliance of the infarcted left ventricle was studied in dogs 3-5 days after occlusion of the left anterior descending coronary artery. Compliance was assessed from postmortem pressure-volume curves and from pressure-length measurements (mercury-in-silastic segment length gauges) made both in vivo and postmortem. Postmortem pressure-volume curves showed reduced compliance compared to sham-operated animals. Postmortem pressure-length curves of infarcted and adjacent normal myocardium indicated that the diminished total compliance could be attributed to an increase in stiffness of the infarcted area. This was confirmed by in vivo end-diastolic pressure-length changes produced by transient aortic occlusion. The infarcted area was akinetic, showing neither contraction nor aneurysmal bulging. In addition, anesthetized dogs with infarcts, when compared with sham-operated animals, had similar left ventricular end-diastolic volumes (indicator dilution method), but higher left ventricular end-diastolic pressures. Taken with previous observations, which show that systolic aneurysmal bulging is uniformly present at the onset of ischemia, these results indicate that stiffening of the ischemic myocardium occurs during the first 5 days after infarction, and show that elevation of left ventricular filling pressure does not necessarily signify ventricular dilatation. The results also suggest a mechanism whereby ventricular performance may improve during recovery from acute myocardial infarction.

Full text

PDF
1318

Images in this article

1320Image
on p.1320

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUSTEN W. G., TSUNEKAWA T., BENDER H. W., EBERT P. A., MORROW A. G. The acute hemodynamic effects of left ventricular aneurysm. J Surg Res. 1962 May;2:161–167. [PubMed] [Google Scholar]
  2. BROCH O. J., HUMERFELT S., HAARSTAD J., MYHRE J. R. Hemodynamic studies in acute myocardial infarction. Am Heart J. 1959 Apr;57(4):522–529. doi: 10.1016/0002-8703(59)90029-8. [DOI] [PubMed] [Google Scholar]
  3. Bergmann W. Der Bindegewebsgehalt im Herzmuskel des Menschen bei akutem und chronischem Myokardinfarkt. Arch Kreislaufforsch. 1968 Jun;56(1):106–126. [PubMed] [Google Scholar]
  4. CASE R. B., BERGLUND E., SARNOFF S. J. Ventricular function. II. Quantitative relationship between coronary flow and ventricular function with observations on unilateral failure. Circ Res. 1954 Jul;2(4):319–325. doi: 10.1161/01.res.2.4.319. [DOI] [PubMed] [Google Scholar]
  5. Carleton R. A., Bowyer A. F., Graettinger J. S. Overestimation of left ventricular volume by the indicator dilution technique. Circ Res. 1966 Mar;18(3):248–256. doi: 10.1161/01.res.18.3.248. [DOI] [PubMed] [Google Scholar]
  6. DODGE H. T., HAY R. E., SANDLER H. Pressure-volume of the diastolic left ventricle of man with heart disease. Am Heart J. 1962 Oct;64:503–511. doi: 10.1016/0002-8703(62)90036-4. [DOI] [PubMed] [Google Scholar]
  7. Forwand S. A., McIntyre K. M., Lipana J. G., Levine H. J. Active stiffness of the intact canine left ventricle. With observations on the effect of acute and chronic myocardial infarction. Circ Res. 1966 Nov;19(5):970–979. doi: 10.1161/01.res.19.5.970. [DOI] [PubMed] [Google Scholar]
  8. GAMMILL J. F., APPLEGARTH J. J., REED C. E., FERNALD J. D., ANTENUCCI A. J. Hemodynamic changes following acute myocardial infarction using the dye injection method for cardiac output determination. Ann Intern Med. 1955 Jul;43(1):100–119. doi: 10.7326/0003-4819-43-1-100. [DOI] [PubMed] [Google Scholar]
  9. GORLIN R., ROLETT E. L., YURCHAK P. M., ELLIOTT W. C. LEFT VENTRICULAR VOLUME IN MAN MEASURED BY THERMODILUTION. J Clin Invest. 1964 Jun;43:1203–1221. doi: 10.1172/JCI105004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. GREENWOOD W. F., ALDRIDGE H. E., WIGLE E. D. THE NATURE OF THE DISORDER OF FUNCTION IN CHRONIC POSTINFARCTION ANEURYSM OF THE LEFT VENTRICLE. Can Med Assoc J. 1965 Mar 20;92:611–614. [PMC free article] [PubMed] [Google Scholar]
  11. HARRIS A. S. Delayed development of ventricular ectopic rhythms following experimental coronary occlusion. Circulation. 1950 Jun;1(6):1318–1328. doi: 10.1161/01.cir.1.6.1318. [DOI] [PubMed] [Google Scholar]
  12. HOLT J. P. Estimation of the residual volume of the ventricle of the dog's heart by two indicator dilution technics. Circ Res. 1956 Mar;4(2):187–195. doi: 10.1161/01.res.4.2.187. [DOI] [PubMed] [Google Scholar]
  13. Heimbecker R. O., Chen C., Hamilton N., Murray D. W. Surgery for massive myocardial infarction. An experimental study of emergency infarctectomy. Surgery. 1967 Jan;61(1):51–58. [PubMed] [Google Scholar]
  14. Hood W. B., Jr, Covelli V. H., Abelmann W. H., Norman J. C. Persistence of contractile behaviour in acutely ischaemic myocardium. Cardiovasc Res. 1969 Jul;3(3):249–260. doi: 10.1093/cvr/3.3.249. [DOI] [PubMed] [Google Scholar]
  15. Hood W. B., Jr Experimental myocardial infarction. 3. Recovery of left ventricular function in the healing phase. Contribution of increased fiber shortening in noninfarcted myocardium. Am Heart J. 1970 Apr;79(4):531–538. doi: 10.1016/0002-8703(70)90259-0. [DOI] [PubMed] [Google Scholar]
  16. Hood W. B., Jr, McCarthy B., Lown B. Aortic pressure loading in dogs with myocardial infarction. Am Heart J. 1969 Jan;77(1):55–62. doi: 10.1016/0002-8703(69)90129-x. [DOI] [PubMed] [Google Scholar]
  17. Hood W. B., Jr, McCarthy B., Lown B. Myocardial infarction following coronary ligation in dogs. Hemodynamic effects of isoproterenol and acetylstrophanthidin. Circ Res. 1967 Aug;21(2):191–199. doi: 10.1161/01.res.21.2.191. [DOI] [PubMed] [Google Scholar]
  18. Klein M. D., Herman M. V., Gorlin R. A hemodynamic study of left ventricular aneurysm. Circulation. 1967 Apr;35(4):614–630. doi: 10.1161/01.cir.35.4.614. [DOI] [PubMed] [Google Scholar]
  19. Kumar R., Hood W. B., Jr, Joison J., Norman J. C., Abelmann W. H. Experimental myocardial infarction. II. Acute depression and subsequent recovery of left ventricular function: serial measurements in intact conscious dogs. J Clin Invest. 1970 Jan;49(1):55–62. doi: 10.1172/JCI106223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. LEE G. J. Total and peripheral blood flow in acute myocardial infarction. Br Heart J. 1957 Jan;19(1):117–128. doi: 10.1136/hrt.19.1.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. LEWIS R. P., BRISTOW J. D., FARREHI C., KLOSTER F. E., GRISWOLD H. E. IDIOPATHIC LEFT VENTRICULAR HYPERTROPHY: A HEMODYNAMIC REAPPRAISAL. Am J Med. 1965 Jun;38:842–852. doi: 10.1016/0002-9343(65)90003-3. [DOI] [PubMed] [Google Scholar]
  22. Laks M. M., Garner D., Swan H. J. Volumes and compliances measured simultaneously in the right and left ventricles of the dog. Circ Res. 1967 May;20(5):565–569. doi: 10.1161/01.res.20.5.565. [DOI] [PubMed] [Google Scholar]
  23. MURPHY G. W., GLICK G., SCHREINER B. F., Jr, YU P. N. Cardiac output in acute myocardial infarction. Serial determination by precordial radioisotope dilution curves. Am J Cardiol. 1963 May;11:587–593. doi: 10.1016/0002-9149(63)90077-8. [DOI] [PubMed] [Google Scholar]
  24. McCarthy B., Hood W. B., Jr, Lown B. Fiberoptic monitoring of cardiac output and hepatic dye clearance in dogs. J Appl Physiol. 1967 Nov;23(5):641–645. doi: 10.1152/jappl.1967.23.5.641. [DOI] [PubMed] [Google Scholar]
  25. Nakhjavan F. K., Son R., Goldberg H. Myocardial contractility in areas with chronic ischaemia: studies on isometric tension. Cardiovasc Res. 1968 Jul;2(3):226–233. doi: 10.1093/cvr/2.3.226. [DOI] [PubMed] [Google Scholar]
  26. SCHLICHTER J., HELLERSTEIN H. K., KATZ L. N. Aneurysm of the heart: a correlative study of one hundred and two proved cases. Medicine (Baltimore) 1954 Feb;33(1):43–86. [PubMed] [Google Scholar]
  27. STONE H. L., BISHOP V. S., GUYTON A. C. Cardiac function after embolization of coronaries with microspheres. Am J Physiol. 1963 Jan;204:16–20. doi: 10.1152/ajplegacy.1963.204.1.16. [DOI] [PubMed] [Google Scholar]
  28. TYSON K., MANDELBAUM I., SHUMACKER H. B., Jr Experimental production and study of left ventricular aneurysms. J Thorac Cardiovasc Surg. 1962 Dec;44:731–737. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES