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. 1986 Mar;83(6):1656–1659. doi: 10.1073/pnas.83.6.1656

AMP-insensitive fructose bisphosphatase in Escherichia coli and its consequences.

J M Sedivy, J Babul, D G Fraenkel
PMCID: PMC323142  PMID: 3006063

Abstract

Inhibition of fructose bisphosphatase (EC 3.1.3.11) by AMP is thought to be an important control mechanism, and, for the Escherichia coli enzyme, is the only control known. We here report on a mutant E. coli fructose bisphosphatase almost insensitive to this inhibition. The purified enzyme is normal in other respects. A strain with this enzyme instead of the wild-type enzyme grows normally in a variety of media. A strain with a very high level of the wild-type enzyme also grows normally. A strain with the very high level of mutant enzyme, however, does show growth abnormalities, but they are not clearly associated with the AMP insensitivity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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