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. 1986 Apr;83(7):2114–2117. doi: 10.1073/pnas.83.7.2114

Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro.

P F Davies, A Remuzzi, E J Gordon, C F Dewey Jr, M A Gimbrone Jr
PMCID: PMC323241  PMID: 3457378

Abstract

The effects of hemodynamic forces upon vascular endothelial cell turnover were studied by exposing contact-inhibited confluent cell monolayers to shear stresses of varying amplitude in either laminar or turbulent flow. Laminar shear stresses (range, 8-15 dynes/cm2; 24 hr) induced cell alignment in the direction of flow without initiating the cell cycle. In contrast, turbulent shear stresses as low as 1.5 dynes/cm2 for as short a period as 3 hr stimulated substantial endothelial DNA synthesis in the absence of cell alignment, discernible cell retraction, or cell loss. The results of these in vitro experiments suggest that in atherosclerotic lesion-prone regions of the vascular system, unsteady blood flow characteristics, rather than the magnitude of wall shear stress per se, may be the major determinant of hemodynamically induced endothelial cell turnover.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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