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. 1986 May;83(10):3398–3401. doi: 10.1073/pnas.83.10.3398

DNA linkage analysis of X chromosome-linked chronic granulomatous disease.

R L Baehner, L M Kunkel, A P Monaco, J L Haines, P M Conneally, C Palmer, N Heerema, S H Orkin
PMCID: PMC323521  PMID: 3010296

Abstract

Chronic granulomatous disease (CGD) is a disorder of phagocytes that is usually inherited as an X chromosome-linked trait. Previous family studies suggested that the CGD locus resides on the distal short arm (Xp22-Xpter). Using cloned, polymorphic DNA probes we have performed a linkage analysis within CGD families that suggests a more proximal location (Xp21). In addition, the CGD locus is proximal to the Duchenne muscular dystrophy locus and lies within a broad region of Xp in which recombination appears to be greater than anticipated on the basis of physical distance between markers. Regional localization of the X chromosome CGD locus should facilitate molecular cloning of the CGD gene and molecular dissection of the phagocyte oxidase system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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