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. 1986 Jun;83(11):3934–3938. doi: 10.1073/pnas.83.11.3934

Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.

K Huebner, A ar-Rushdi, C A Griffin, M Isobe, C Kozak, B S Emanuel, L Nagarajan, J L Cleveland, T I Bonner, M D Goldsborough, et al.
PMCID: PMC323639  PMID: 3520560

Abstract

Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments homologous to mA-raf cDNA cosegregate with mouse chromosome X in a panel of Chinese hamster-mouse hybrid cells, thus localizing the mA-raf locus to mouse chromosome X. Two independently segregating loci, detected by the hA-raf cDNA (or mA-raf cDNA), hA-raf-1 and hA-raf-2, are located on human chromosomes X and 7, respectively. The mA-raf locus and the hA-raf-1 locus are actively transcribed in several mouse and human cell lines.

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