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. 1980 Oct 24;8(20):4681–4687. doi: 10.1093/nar/8.20.4681

Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains.

U Storb, B Arp, R Wilson
PMCID: PMC324379  PMID: 6255428

Abstract

In many myelomas more than one kappa gene is rearranged (2-5). We are reporting here the results of studies undertaken to determine whether all the rearranged genes are expressed. It was found that in the myeloma NS-1 three different rearranged kappa genes exist. In a subline of NS-1 and several hybridomas produced by fusion of mouse spleen cells with NS-1 it was found that production of NS-1 kappa chains was correlated with the presence of one of the three kappa genes. Loss of this "expressed" gene eliminated the synthesis of the NS-1 kappa chains, loss of one of the other two rearranged kappa genes did not. It is hypothesized, that allelic exclusion (20) of kappa genes generally operates by the functional rearrangement of one kappa gene; other rearrangements are relatively frequent, at least in myelomas, but mostly they are nonfunctional and thus scrambled antibody molecules do not arise.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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