Abstract
Churg-Strauss syndrome is a disseminated vasculitis with multisystem involvement, characterized by necrotizing arteritis, eosinophilic infiltration, and extravascular granuloma formation. In as many as 60% of all cases, the heart may be affected. We describe a 30-year-old man in whom pericarditis was followed by the development of a large pericardial effusion, with evidence of impaired right and left ventricular function. The patient had a 5-year history of asthma. Early therapy with high-dose prednisolone and azathioprine led to resolution of the pericardial effusion and prevented a further reduction in biventricular function. (Texas Heart Institute Journal 1991;18:127-31)
Keywords: Churg-Strauss syndrome
Keywords: echocardiography
Keywords: eosinophilia
Keywords: eosinophilic granuloma
Keywords: myocarditis
Keywords: pericarditis
Keywords: vasculitis
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CHURG J., STRAUSS L. Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol. 1951 Mar-Apr;27(2):277–301. [PMC free article] [PubMed] [Google Scholar]
- Chumbley L. C., Harrison E. G., Jr, DeRemee R. A. Allergic granulomatosis and angiitis (Churg-Strauss syndrome). Report and analysis of 30 cases. Mayo Clin Proc. 1977 Aug;52(8):477–484. [PubMed] [Google Scholar]
- Davison A. G., Thompson P. J., Davies J., Corrin B., Turner-Warwick M. Prominent pericardial and myocardial lesions in the Churg-Strauss syndrome (allergic granulomatosis and angiitis). Thorax. 1983 Oct;38(10):793–795. doi: 10.1136/thx.38.10.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lanham J. G., Cooke S., Davies J., Hughes G. R. Endomyocardial complications of the Churg-Strauss syndrome. Postgrad Med J. 1985 Apr;61(714):341–344. doi: 10.1136/pgmj.61.714.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lanham J. G., Elkon K. B., Pusey C. D., Hughes G. R. Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome. Medicine (Baltimore) 1984 Mar;63(2):65–81. doi: 10.1097/00005792-198403000-00001. [DOI] [PubMed] [Google Scholar]
- Lie J. T., Bayardo R. J. Isolated eosinophilic coronary arteritis and eosinophilic myocarditis. A limited form of Churg-Strauss syndrome. Arch Pathol Lab Med. 1989 Feb;113(2):199–201. [PubMed] [Google Scholar]
- Lie J. T. The classification of vasculitis and a reappraisal of allergic granulomatosis and angiitis (Churg-Strauss syndrome). Mt Sinai J Med. 1986 Jun;53(6):429–439. [PubMed] [Google Scholar]
- Morgan J. M., Raposo L., Gibson D. G. Cardiac involvement in Churg-Strauss syndrome shown by echocardiography. Br Heart J. 1989 Dec;62(6):462–466. doi: 10.1136/hrt.62.6.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Olsen E. G., Spry C. J. Relation between eosinophilia and endomyocardial disease. Prog Cardiovasc Dis. 1985 Jan-Feb;27(4):241–254. doi: 10.1016/0033-0620(85)90008-8. [DOI] [PubMed] [Google Scholar]
- Pincus S. H., Schooley W. R., DiNapoli A. M., Broder S. Metabolic heterogeneity of eosinophils from normal and hypereosinophilic patients. Blood. 1981 Dec;58(6):1175–1181. [PubMed] [Google Scholar]
- Tai P. C., Hayes D. J., Clark J. B., Spry C. J. Toxic effects of human eosinophil products on isolated rat heart cells in vitro. Biochem J. 1982 Apr 15;204(1):75–80. doi: 10.1042/bj2040075. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tai P. C., Spry C. J. Enzymes altering the binding capacity of human blood eosinophils for IgG antibody-coated erythrocytes (EA). Clin Exp Immunol. 1980 Apr;40(1):206–219. [PMC free article] [PubMed] [Google Scholar]
- Thomson D., Chamsi-Pasha H., Hasleton P. Heart transplantation for Churg-Strauss syndrome. Br Heart J. 1989 Nov;62(5):409–410. doi: 10.1136/hrt.62.5.409. [DOI] [PMC free article] [PubMed] [Google Scholar]