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. 1983 Nov 25;11(22):8031–8036. doi: 10.1093/nar/11.22.8031

Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine.

B C Froehler, M D Matteucci
PMCID: PMC326557  PMID: 6606157

Abstract

Sterically hindered N6-dialkylformamidine protected deoxyadenosine is more stable to acidic depurination than N6-benzoyldeoxyadenosine and is potentially a valuable protecting group in the synthesis of deoxyoligonucleotides.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chow F., Kempe T., Palm G. Synthesis of oligodeoxyribonucleotides on silica gel support. Nucleic Acids Res. 1981 Jun 25;9(12):2807–2817. doi: 10.1093/nar/9.12.2807. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Letsinger R. L., Miller P. S., Grams G. W. Selective N-debenzoylation of N,O-polybenzoylucleosides. Tetrahedron Lett. 1968 Apr;(22):2621–2624. doi: 10.1016/s0040-4039(00)89658-6. [DOI] [PubMed] [Google Scholar]
  3. Tanaka T., Letsinger R. L. Syringe method for stepwise chemical synthesis of oligonucleotides. Nucleic Acids Res. 1982 May 25;10(10):3249–3260. doi: 10.1093/nar/10.10.3249. [DOI] [PMC free article] [PubMed] [Google Scholar]

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