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. 1981 Mar 11;9(5):1219–1228. doi: 10.1093/nar/9.5.1219

The interaction of polyamines with DNA: a 23Na NMR study.

D R Burton, S Forsén, P Reimarsson
PMCID: PMC326747  PMID: 7232215

Abstract

The interaction between a variety of polyamines, both naturally occurring and synthetic, and calf thymus DNA has been studied using 23Na NMR. The relaxation behaviour of 23Na reflects the extent of interaction of Na+ with DNA phosphate groups and therefore the extent of charge neutralisation of DNA phosphate groups (P) by polyamine amino and imino groups (N) in solutions of DNa, polyamine and Na+. The studies reveal that whereas spermine and spermidine are capable of expelling nearly all of the Na+ ions from DNA at N/P approximately 1, diamines such as putrescine and homologues of spermine and spermidine are capable of neutralising only roughly 50% of DNA phosphates. The results provide a challenge to current models of DNA-polyamine interactions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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