Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1986 Jul;78(1):1–5. doi: 10.1172/JCI112536

Cyclic guanosine monophosphate as a mediator of vasodilation.

F Murad
PMCID: PMC329522  PMID: 2873150

Full text

PDF
5

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anand-Srivastava M. B., Franks D. J., Cantin M., Genest J. Atrial natriuretic factor inhibits adenylate cyclase activity. Biochem Biophys Res Commun. 1984 Jun 29;121(3):855–862. doi: 10.1016/0006-291x(84)90756-3. [DOI] [PubMed] [Google Scholar]
  2. Arnold W. P., Mittal C. K., Katsuki S., Murad F. Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3203–3207. doi: 10.1073/pnas.74.8.3203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brandwein H. J., Lewicki J. A., Murad F. Reversible inactivation of guanylate cyclase by mixed disulfide formation. J Biol Chem. 1981 Mar 25;256(6):2958–2962. [PubMed] [Google Scholar]
  4. Braughler J. M., Mittal C. K., Murad F. Effects of thiols, sugars, and proteins on nitric oxide activation of guanylate cyclase. J Biol Chem. 1979 Dec 25;254(24):12450–12454. [PubMed] [Google Scholar]
  5. Cocks T. M., Angus J. A., Campbell J. H., Campbell G. R. Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture. J Cell Physiol. 1985 Jun;123(3):310–320. doi: 10.1002/jcp.1041230304. [DOI] [PubMed] [Google Scholar]
  6. Craven P. A., DeRubertis F. R., Pratt D. W. Electron spin resonance study of the role of NO . catalase in the activation of guanylate cyclase by NaN3 and NH2OH. Modulation of enzyme responses by heme proteins and their nitrosyl derivatives. J Biol Chem. 1979 Sep 10;254(17):8213–8222. [PubMed] [Google Scholar]
  7. Currie M. G., Geller D. M., Cole B. R., Boylan J. G., YuSheng W., Holmberg S. W., Needleman P. Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria. Science. 1983 Jul 1;221(4605):71–73. doi: 10.1126/science.6857267. [DOI] [PubMed] [Google Scholar]
  8. De Léan A., Racz K., Gutkowska J., Nguyen T. T., Cantin M., Genest J. Specific receptor-mediated inhibition by synthetic atrial natriuretic factor of hormone-stimulated steroidogenesis in cultured bovine adrenal cells. Endocrinology. 1984 Oct;115(4):1636–1638. doi: 10.1210/endo-115-4-1636. [DOI] [PubMed] [Google Scholar]
  9. DeRubertis F. R., Craven P. A. Calcium-independent modulation of cyclic GMP and activation of guanylate cyclase by nitrosamines. Science. 1976 Sep 3;193(4256):897–899. doi: 10.1126/science.7837. [DOI] [PubMed] [Google Scholar]
  10. Diamond J., Blisard K. S. Effects of stimulant and relaxant drugs on tension and cyclic nucleotide levels in canine femoral artery. Mol Pharmacol. 1976 Jul;12(4):668–692. [PubMed] [Google Scholar]
  11. Field M., Graf L. H., Jr, Laird W. J., Smith P. L. Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2800–2804. doi: 10.1073/pnas.75.6.2800. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Fiscus R. R., Rapoport R. M., Murad F. Endothelium-dependent and nitrovasodilator-induced activation of cyclic GMP-dependent protein kinase in rat aorta. J Cyclic Nucleotide Protein Phosphor Res. 1983;9(6):415–425. [PubMed] [Google Scholar]
  13. Fiscus R. R., Rapoport R. M., Waldman S. A., Murad F. Atriopeptin II elevates cyclic GMP, activates cyclic GMP-dependent protein kinase and causes relaxation in rat thoracic aorta. Biochim Biophys Acta. 1985 Jul 30;846(1):179–184. doi: 10.1016/0167-4889(85)90124-7. [DOI] [PubMed] [Google Scholar]
  14. Fiscus R. R., Torphy T. J., Mayer S. E. Cyclic GMP-dependent protein kinase activation in canine tracheal smooth muscle by methacholine and sodium nitroprusside. Biochim Biophys Acta. 1984 Dec 11;805(4):382–392. doi: 10.1016/0167-4889(84)90022-3. [DOI] [PubMed] [Google Scholar]
  15. Furchgott R. F. The role of endothelium in the responses of vascular smooth muscle to drugs. Annu Rev Pharmacol Toxicol. 1984;24:175–197. doi: 10.1146/annurev.pa.24.040184.001135. [DOI] [PubMed] [Google Scholar]
  16. Gerzer R., Böhme E., Hofmann F., Schultz G. Soluble guanylate cyclase purified from bovine lung contains heme and copper. FEBS Lett. 1981 Sep 14;132(1):71–74. doi: 10.1016/0014-5793(81)80429-2. [DOI] [PubMed] [Google Scholar]
  17. Griffith T. M., Edwards D. H., Lewis M. J., Newby A. C., Henderson A. H. The nature of endothelium-derived vascular relaxant factor. Nature. 1984 Apr 12;308(5960):645–647. doi: 10.1038/308645a0. [DOI] [PubMed] [Google Scholar]
  18. Guerrant R. L., Hughes J. M., Chang B., Robertson D. C., Murad F. Activation of intestinal guanylate cyclase by heat-stable enterotoxin of Escherichia coli: studies of tissue specificity, potential receptors, and intermediates. J Infect Dis. 1980 Aug;142(2):220–228. doi: 10.1093/infdis/142.2.220. [DOI] [PubMed] [Google Scholar]
  19. Holzmann S. Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips. J Cyclic Nucleotide Res. 1982;8(6):409–419. [PubMed] [Google Scholar]
  20. Hughes J. M., Murad F., Chang B., Guerrant R. L. Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli. Nature. 1978 Feb 23;271(5647):755–756. doi: 10.1038/271755a0. [DOI] [PubMed] [Google Scholar]
  21. Ignarro L. J., Ballot B., Wood K. S. Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins. J Biol Chem. 1984 May 25;259(10):6201–6207. [PubMed] [Google Scholar]
  22. Katsuki S., Arnold W. P., Murad F. Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues. J Cyclic Nucleotide Res. 1977 Aug;3(4):239–247. [PubMed] [Google Scholar]
  23. Katsuki S., Arnold W., Mittal C., Murad F. Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J Cyclic Nucleotide Res. 1977 Feb;3(1):23–35. [PubMed] [Google Scholar]
  24. Katsuki S., Murad F. Regulation of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate levels and contractility in bovine tracheal smooth muscle. Mol Pharmacol. 1977 Mar;13(2):330–341. [PubMed] [Google Scholar]
  25. Kimura H., Mittal C. K., Murad F. Activation of guanylate cyclase from rat liver and other tissues by sodium azide. J Biol Chem. 1975 Oct 25;250(20):8016–8022. [PubMed] [Google Scholar]
  26. Kimura H., Mittal C. K., Murad F. Increases in cyclic GMP levels in brain and liver with sodium azide an activator of guanylate cyclase. Nature. 1975 Oct 23;257(5528):700–702. doi: 10.1038/257700a0. [DOI] [PubMed] [Google Scholar]
  27. Kobayashi S., Kanaide H., Nakamura M. Cytosolic-free calcium transients in cultured vascular smooth muscle cells: microfluorometric measurements. Science. 1985 Aug 9;229(4713):553–556. doi: 10.1126/science.3927484. [DOI] [PubMed] [Google Scholar]
  28. Kukovetz W. R., Holzmann S., Wurm A., Pöch G. Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 1979 Dec;310(2):129–138. doi: 10.1007/BF00500277. [DOI] [PubMed] [Google Scholar]
  29. Leitman D. C., Murad F. Comparison of binding and cyclic GMP accumulation by atrial natriuretic peptides in endothelial cells. Biochim Biophys Acta. 1986 Jan 23;885(1):74–79. doi: 10.1016/0167-4889(86)90040-6. [DOI] [PubMed] [Google Scholar]
  30. Mittal C. K., Arnold W. P., Murad F. Characterization of protein inhibitors of guanylate cyclase activation from rat heart and bovine lung. J Biol Chem. 1978 Feb 25;253(4):1266–1271. [PubMed] [Google Scholar]
  31. Mittal C. K., Kimura H., Murad F. Purification and properties of a protein required for sodium azide activation of guanylate cyclase. J Biol Chem. 1977 Jun 25;252(12):4384–4390. [PubMed] [Google Scholar]
  32. Mittal C. K., Murad F. Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3',5'-monophosphate formation. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4360–4364. doi: 10.1073/pnas.74.10.4360. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Murad F., Arnold W. P., Mittal C. K., Braughler J. M. Properties and regulation of guanylate cyclase and some proposed functions for cyclic GMP. Adv Cyclic Nucleotide Res. 1979;11:175–204. [PubMed] [Google Scholar]
  34. Nakayama K., Ohkubo H., Hirose T., Inayama S., Nakanishi S. mRNA sequence for human cardiodilatin-atrial natriuretic factor precursor and regulation of precursor mRNA in rat atria. Nature. 1984 Aug 23;310(5979):699–701. doi: 10.1038/310699a0. [DOI] [PubMed] [Google Scholar]
  35. Pearl R. G., Rosenthal M. H., Murad F., Ashton J. P. Aminophylline potentiates sodium nitroprusside-induced hypotension in the dog. Anesthesiology. 1984 Dec;61(6):712–715. doi: 10.1097/00000542-198412000-00014. [DOI] [PubMed] [Google Scholar]
  36. Rapoport R. M., Draznin M. B., Murad F. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature. 1983 Nov 10;306(5939):174–176. doi: 10.1038/306174a0. [DOI] [PubMed] [Google Scholar]
  37. Rapoport R. M., Draznin M. B., Murad F. Endothelium-dependent vasodilator-and nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic GMP-dependent protein phosphorylation. Trans Assoc Am Physicians. 1983;96:19–30. [PubMed] [Google Scholar]
  38. Rapoport R. M., Draznin M. B., Murad F. Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta. Circ Res. 1984 Oct;55(4):468–479. doi: 10.1161/01.res.55.4.468. [DOI] [PubMed] [Google Scholar]
  39. Rapoport R. M., Draznin M. B., Murad F. Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. Proc Natl Acad Sci U S A. 1982 Nov;79(21):6470–6474. doi: 10.1073/pnas.79.21.6470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Rapoport R. M., Murad F. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ Res. 1983 Mar;52(3):352–357. doi: 10.1161/01.res.52.3.352. [DOI] [PubMed] [Google Scholar]
  41. Rapoport R. M., Murad F. Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP. J Cyclic Nucleotide Protein Phosphor Res. 1983;9(4-5):281–296. [PubMed] [Google Scholar]
  42. Rapoport R. M., Schwartz K., Murad F. Effect of sodium-potassium pump inhibitors and membrane-depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circ Res. 1985 Jul;57(1):164–170. doi: 10.1161/01.res.57.1.164. [DOI] [PubMed] [Google Scholar]
  43. Rapoport R. M., Waldman S. A., Schwartz K., Winquist R. J., Murad F. Effects of atrial natriuretic factor, sodium nitroprusside, and acetylcholine on cyclic GMP levels and relaxation in rat aorta. Eur J Pharmacol. 1985 Sep 24;115(2-3):219–229. doi: 10.1016/0014-2999(85)90694-6. [DOI] [PubMed] [Google Scholar]
  44. Schultz K., Schultz K., Schultz G. Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens. Nature. 1977 Feb 24;265(5596):750–751. doi: 10.1038/265750a0. [DOI] [PubMed] [Google Scholar]
  45. Vandlen R. L., Arcuri K. E., Napier M. A. Identification of a receptor for atrial natriuretic factor in rabbit aorta membranes by affinity cross-linking. J Biol Chem. 1985 Sep 15;260(20):10889–10892. [PubMed] [Google Scholar]
  46. Waldman S. A., Rapoport R. M., Murad F. Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues. J Biol Chem. 1984 Dec 10;259(23):14332–14334. [PubMed] [Google Scholar]
  47. Waldman S. A., Sinacore M. S., Lewicki J. A., Chang L. Y., Murad F. Selective activation of particulate guanylate cyclase by a specific class of porphyrins. J Biol Chem. 1984 Apr 10;259(7):4038–4042. [PubMed] [Google Scholar]
  48. Winquist R. J., Faison E. P., Waldman S. A., Schwartz K., Murad F., Rapoport R. M. Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7661–7664. doi: 10.1073/pnas.81.23.7661. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Yamanaka M., Greenberg B., Johnson L., Seilhamer J., Brewer M., Friedemann T., Miller J., Atlas S., Laragh J., Lewicki J. Cloning and sequence analysis of the cDNA for the rat atrial natriuretic factor precursor. Nature. 1984 Jun 21;309(5970):719–722. doi: 10.1038/309719a0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES