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. 1991 Mar;87(3):842–846. doi: 10.1172/JCI115088

Antibodies elicited by pneumococcal antigens bear an anti-DNA--associated idiotype.

A Grayzel 1, A Solomon 1, C Aranow 1, B Diamond 1
PMCID: PMC329872  PMID: 1999497

Abstract

There is evidence in both murine and human lupus that the production of anti-DNA antibodies may be triggered by environmental antigens. To explore this further, we studied the serum of 10 nonautoimmune individuals immunized with a polyvalent pneumococcal polysaccharide vaccine. All 10 patients showed a rise in the titer of antipneumococcal antibodies bearing an anti-DNA-associated idiotype. The antipneumococcal response was specific as no idiotypic antitetanus antibodies were detected. Furthermore, no anti-DNA antibodies were present in postvaccination sera. The molecular analysis of antipneumococcal and anti-DNA antibodies bearing a common idiotype will help elucidate how foreign antigen might lead to the production of anti-DNA antibodies in susceptible individuals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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