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. 1990 Jun 11;18(11):3155–3159. doi: 10.1093/nar/18.11.3155

HELP (high efficiency liquid phase) new oligonucleotide synthesis on soluble polymeric support.

G M Bonora 1, C L Scremin 1, F P Colonna 1, A Garbesi 1
PMCID: PMC330918  PMID: 2356115

Abstract

A simple, rapid and high-yielding method for the synthesis of oligonucleotides by the phosphotriesters approach is described. The use of polyethylene glycol (PEG) as soluble polymeric support preserves some convenient features of the solid-phase synthesis with new interesting advantages. Short oligonucleotides in hundred milligrams scale can be obtained from few grams of functionalized PEG.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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