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. 1975 Dec;56(6):1597–1607. doi: 10.1172/JCI108242

Mechanisms of endotoxin tolerance. The role of the spleen.

S E Greisman, E J Young, J B Workman, R M Ollodart, R B Hornick
PMCID: PMC333139  PMID: 1104660

Abstract

Splenectomy markedly impaired the production of circulating anti-endotoxin antibodies during the initial 10 days after .v. administration of a Boivin preparation of Escherichia coli endotoxin (ET) in both rabbit and man. Increase in antibodies with secondary (flocculating and bactericidal) activities were virtually abolished, whereas increases in antibodies with primary (binding) activity were significantly reduced. On the basis of these findings, splenectomized rabbit and man were employed to test the hypothesis that the early phase (less than 72 h) of pyrogenic tolerance to endotoxin is independent of anti-endotoxin antibody but that such antibody contributes significantly to the later phase (less than or equal to 72 h) of tolerance. In the splenectomized rabbit, the initial pyrogenic reponses to ET and the subsequent tolerant responses at 24 and 48 h were comparable to sham-operated controls...

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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