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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1976 Mar;73(3):895–899. doi: 10.1073/pnas.73.3.895

Assignment of the AK1:Np:ABO linkage group to human chromosome 9.

A Westerveld, A P Jongsma, P Meera Khan, H van Someren, D Bootsma
PMCID: PMC336026  PMID: 176661

Abstract

In man-Chinese hamster somatic cell hybrids the segregation patterns of the loci for 25 human enzyme markers and human chromosomes were studied. The results provide evidence for the localization of the gene for adenylate kinase-1 (AK1) on chromosome 9. Since the loci for the ABO blood group (ABO), nail-patella syndrome (Np), and AK1 are known to be linked in man, the ABO:Np:AK1 linkage group may be assigned to chromosome 9.

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Selected References

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  1. Arias S., Mota M., Yánez A., Bolivar M. Probable loose linkage between the ABO locus and Waardenburg syndrome type I. Humangenetik. 1975;27(2):145–149. doi: 10.1007/BF00273330. [DOI] [PubMed] [Google Scholar]
  2. Bobrow M., Madan K., Pearson P. L. Staining of some specific regions of human chromosomes, particularly the secondary constriction of No. 9. Nat New Biol. 1972 Jul 26;238(82):122–124. doi: 10.1038/newbio238122a0. [DOI] [PubMed] [Google Scholar]
  3. Bowman J. E., Frischer H., Ajmar F., Carson P. E., Gower M. K. Population, family and biochemical investigation of human adenylate kinase polymorphism. Nature. 1967 Jun 10;214(5093):1156–1158. doi: 10.1038/2141156a0. [DOI] [PubMed] [Google Scholar]
  4. Brock D. J. Adenylate kinase isoenzyme patterns in tissues of people of different phenotype. Biochem Genet. 1970 Oct;4(5):617–625. doi: 10.1007/BF00486099. [DOI] [PubMed] [Google Scholar]
  5. Burgerhout W. Identification of interspecific translocation chromosomes in human-Chinese hamster hybrid cells. Humangenetik. 1975 Sep 23;29(3):229–231. doi: 10.1007/BF00297628. [DOI] [PubMed] [Google Scholar]
  6. Burgerhout W., van Someren H., Bootsma D. Cytological mapping of the genes assigned to the human A 1 chromosome by use of radiation-induced chromosome breakage in a human-Chinese hamster hybrid cell line. Humangenetik. 1973;20(2):159–162. doi: 10.1007/BF00284852. [DOI] [PubMed] [Google Scholar]
  7. EL-HEFNAWI H., SMITH S. M., PENROSE L. S. XERODERMA PIGMENTOSUM--ITS INHERITANCE AND RELATIONSHIP TO THE ABO BLOOD-GROUP SYSTEM. Ann Hum Genet. 1965 Mar;28:273–290. doi: 10.1111/j.1469-1809.1964.tb00483.x. [DOI] [PubMed] [Google Scholar]
  8. Ferguson-Smith M. A., Ellis P. M., Mutchinick O., Glen K. P., Côté G. B., Edwards J. H. Centromeric linkage. Birth Defects Orig Artic Ser. 1975;11(3):130–137. [PubMed] [Google Scholar]
  9. Fildes R. A., Harris H. Genetically determined variation of adenylate kinase in man. Nature. 1966 Jan 15;209(5020):261–263. doi: 10.1038/209261a0. [DOI] [PubMed] [Google Scholar]
  10. Jongsma A., van Someren H., Westerveld A., Hagemeijer A., Pearson P. Localization of genes on human chromosomes by studies of human-Chinese hamster somatic cell hybrids. Assignment of PGM3 to chromosome C6 and regional mapping of the PGD, PGM1 and pep-C genes on chromosome A1. Humangenetik. 1973 Dec 10;20(3):195–202. doi: 10.1007/BF00385730. [DOI] [PubMed] [Google Scholar]
  11. Meera Khan P. Enzyme electrophoresis on cellulose acetate gel: zymogram patterns in mgh-mouse and man--Chinese hamster somatic cell hybrids. Arch Biochem Biophys. 1971 Aug;145(2):470–483. doi: 10.1016/s0003-9861(71)80007-3. [DOI] [PubMed] [Google Scholar]
  12. RENWICK J. H., LAWLER S. D. Genetical linkage between the ABO and nail-patella loci. Ann Hum Genet. 1955 Jun;19(4):312–331. doi: 10.1111/j.1469-1809.1955.tb01356.x. [DOI] [PubMed] [Google Scholar]
  13. Rapley S., Robson E. B., Harris H., Smith S. M. Data on the incidence, segregation and linkage relations of the adenylate kinase (AK) polymorphism. Ann Hum Genet. 1968 Jan;31(3):237–242. doi: 10.1111/j.1469-1809.1968.tb00554.x. [DOI] [PubMed] [Google Scholar]
  14. Ruddle F., Ricciuti F., McMorris F. A., Darlington G., Chen T. Somatic cell genetic assignment of peptidase C and the Rh linkage group to chromosome A-1 in man. Science. 1972 Jun 30;176(4042):1429–1431. doi: 10.1126/science.176.4042.1429. [DOI] [PubMed] [Google Scholar]
  15. Schleutermann D. A., Bias W. B., Murdoch J. L., McKusick V. A. Linkage of the loci for the nail-patella syndrome and adenylate kinase. Am J Hum Genet. 1969 Nov;21(6):606–630. [PMC free article] [PubMed] [Google Scholar]
  16. Shows T. B. Genetics of human-mouse somatic cell hybrids: linkage of human genes for lactate dehydrogenase-A and esterase-A 4 . Proc Natl Acad Sci U S A. 1972 Feb;69(2):348–352. doi: 10.1073/pnas.69.2.348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Simpson J. L., Falk C. T., Morillo-Cucci G., Allen F. H., Jr, German J. Analysis for possible linkage between the loci for the Waardenburg syndrome and various blood groups and serological traits. Humangenetik. 1974 Jun 26;23(1):45–50. doi: 10.1007/BF00295681. [DOI] [PubMed] [Google Scholar]
  18. Van-Cong-Nguyen, Billardon C., Rebourcet R., Le Borgne de Kaouel C., Picard J. Y., Weil D., Frézal J. Existence probable d'un second locus de AK Lié au groupe PGM 1 -peptidase. Ann Genet. 1972 Dec;15(4):213–218. [PubMed] [Google Scholar]
  19. Weitkamp L. R., Sing C. F., Shreffler D. C., Guttormsen S. A. The genetic linkage relations of adenylate kinase: further data on the ABO-AK linkage group. Am J Hum Genet. 1969 Nov;21(6):600–605. [PMC free article] [PubMed] [Google Scholar]
  20. Westerveld A., Visser R. P., Meera Khan P., Bootsma D. Loss of human genetic markers in man--Chinese hamster somatic cell hybrids. Nat New Biol. 1971 Nov 3;234(44):20–24. doi: 10.1038/newbio234020a0. [DOI] [PubMed] [Google Scholar]
  21. Yoder F. E., Bias W. B., Borgaonkar D. S., Bahr G. F., Yoder I. I., Yoder O. C., Golomb H. M. Cytogenetic and linkage studies of a familial 15pplus variant. Am J Hum Genet. 1974 Sep;26(5):535–548. [PMC free article] [PubMed] [Google Scholar]
  22. van Someren H., Beijersbergen van Henegouwen H., Los W., Wurzer-Figurelli E., Doppert B., Vervloet M., Meera Khan P. Enzyme electrophoresis on cellulose acetate gel. II. Zymogram patterns in man-Chinese hamster somatic cell hybrids. Humangenetik. 1974;25(3):189–201. doi: 10.1007/BF00281426. [DOI] [PubMed] [Google Scholar]

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