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. 1988 Jun 10;16(11):4957–4966. doi: 10.1093/nar/16.11.4957

A novel effect of EGF on mRNA stability.

Y Jinno 1, G T Merlino 1, I Pastan 1
PMCID: PMC336709  PMID: 3260374

Abstract

Expression of the epidermal growth factor (EGF) receptor gene is stimulated by EGF and the phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA). PMA elevates EGF receptor mRNA levels in human KB epidermoid carcinoma cells, but does not significantly affect the half-life of this mRNA when its decay is examined after the addition of actinomycin D. In contrast, EGF greatly prolongs the half-life of EGF receptor mRNA suggesting a possible mechanism for the stimulatory effect of EGF on EGF receptor mRNA levels. EGF also stabilizes beta-tubulin and beta-actin mRNAs but has very little effect on the degradation of total mRNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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