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. 1988 Jun 10;16(11):5107–5113. doi: 10.1093/nar/16.11.5107

Inhibition of DNA polymerase alpha by aphidicolin derivatives.

L Arabshahi 1, N Brown 1, N Khan 1, G Wright 1
PMCID: PMC336720  PMID: 3133639

Abstract

17-Acetylaphidicolin was 10-fold weaker and two derivatives lacking hydroxyl groups at the 16 and 17 positions were 100-fold weaker than aphidicolin as inhibitors of DNA polymerase alpha from HeLa and Chinese hamster ovary cells. 17,18-Diacetyl, 3,17,18-triacetyl and 3-epi derivatives of aphidicolin were inactive. Active compounds were, like aphidicolin, competitive with dCTP and did not inhibit aphidicolin-resistant DNA polymerases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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