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. 1988 Aug 11;16(15):7241–7251. doi: 10.1093/nar/16.15.7241

Insertion of a retrotransposon within the 3' end of a mouse gene provides a new functional polyadenylation signal.

T Baumruker 1, C Gehe 1, I Horak 1
PMCID: PMC338406  PMID: 2842729

Abstract

A site of genomic insertion of the mouse retrotransposon LTR-IS/MuRRS was analysed. The comparison of the genomic and the cDNA clones indicates the insertion of the LTR-IS element into the 3' untranslated region of a mouse gene. The fact that the isolated cDNA clone ends with a poly A tail 20 nucleotides downstream from the LTR-IS AATAAA box and the result of the S1-nuclease mapping provides evidence that the 3' end of the mouse gene transcript was generated under the control of the LTR-IS polyadenylation signal.

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