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. 1988 Sep 26;16(18):9017–9026. doi: 10.1093/nar/16.18.9017

Conservation of short patches of amino acid sequence amongst proteins with a common function but evolutionarily distinct origins: implications for cloning genes and for structure-function analysis.

J K Reichardt 1, P Berg 1
PMCID: PMC338649  PMID: 2845364

Abstract

Small patches of identical amino acid sequences commonly occur in proteins that have the same function but are derived from evolutionarily distant organisms. Reverse translation of such patches into degenerate pools of oligonucleotides provide useful hybridization probes for cloning the gene for the corresponding protein from other organisms. Since the conserved patches of identical amino acid sequence are probably important for the protein's biological function, they are preferred targets for reverse genetic studies aimed at defining structure-function relationships.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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