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. 1988 Nov 11;16(21):9979–9993. doi: 10.1093/nar/16.21.9979

A new member of the ras gene superfamily identified in a rat liver cell line.

C Bucci 1, R Frunzio 1, L Chiariotti 1, A L Brown 1, M M Rechler 1, C B Bruni 1
PMCID: PMC338831  PMID: 3057452

Abstract

A new member of the ras genes superfamily was isolated from a cDNA library derived from a rat liver cell line (BRL-3A). The predicted 201 amino acids ras-like protein shows 30-35% homology with other members of the ras and ras-related gene products so far described. Conserved features include the GTP-binding and hydrolysis domains and the carboxyl terminal cysteine residues. A protein of the expected size (Mr 23,000) was synthesized in an in vitro transcription-translation system. The BRL-ras gene is present in single copy in the rat genome and is ubiquitously expressed at high levels in all tissues and cell lines examined.

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Selected References

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