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. 1986 Feb 11;14(3):1279–1291. doi: 10.1093/nar/14.3.1279

The tetraribonucleotide rCpGpCpG forms a left-handed Z-RNA double-helix.

P W Davis, K Hall, P Cruz, I Tinoco Jr, T Neilson
PMCID: PMC339503  PMID: 3951987

Abstract

NMR and circular dichroism studies show that the RNA tetranucleotide rCpGpCpG can form a Z-RNA left-handed double-helix. In 1.0 M NaClO4, circular dichroism measurements indicate that the tetramer is in the A-form. In 6.0 M NaClO4, there is a characteristic change in the circular dichroism, indicating that the tetramer adopts a left-handed Z-form. This conformation is verified by phosphorus and proton NMR studies. The 31P spectrum shows a large downfield shift in one of the resonances upon an increase in salt concentration. Proton nuclear Overhauser effect (NOE) experiments indicate that the guanosines are in the syn conformation. These results are consistent with the formation of a Z-form double-helix.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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