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. 1987 Mar 11;15(5):2221–2234. doi: 10.1093/nar/15.5.2221

DNA sequence preferences for an intercalating porphyrin compound revealed by footprinting.

K Ford, K R Fox, S Neidle, M J Waring
PMCID: PMC340629  PMID: 3562226

Abstract

The DNA sequence preferences of the compound meso-tetra-(4-N-methyl(pyridyl) porphyrin and its nickel complex have been investigated by means of footprinting experiments on several DNA fragments, using DNAase I and micrococcal nuclease as footprinting agents. A complex pattern of both AT and GC-protected sites was found. Ligand-induced long-range conformational changes were inferred in several instances to be related to the observed large-scale blockages of enzymatic cutting.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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