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. 1987 Mar 25;15(6):2699–2705. doi: 10.1093/nar/15.6.2699

The human kappa deleting element and the mouse recombining segment share DNA sequence homology.

K A Siminovitch, M W Moore, J Durdik, E Selsing
PMCID: PMC340678  PMID: 3104881

Abstract

We have used cloned mouse and human DNA probes to identify regions of conserved homology between the human and murine DNA segments, (termed kappa deleting element (kde) and recombining segment (RS) respectively) which are frequently recombined in lambda-producing B cells. Heteroduplex analysis indicated extensive homology in the region immediately downstream of the recombination site of both segments. This was confirmed by Southern and direct nucleotide sequence analyses. Fifty percent homology was detected within the 500 nucleotides that neighbour the recombination points in the kde and RS segments. These results indicate that the kde and RS sequences are evolutionarily conserved and may be functionally relevant to normal B cell development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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