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. 1978 Jun;5(6):1779–1799. doi: 10.1093/nar/5.6.1779

Characterization of a mouse DNA clone containing an immunoglobulin variable region gene.

N Hozumi, C Brack, V Pirrotta, R Lenhard-Schuller, S Tonegawa
PMCID: PMC342125  PMID: 97634

Abstract

A 4.8 kilobase mouse embryo DNA fragment was inserted into a phage lambda genome and was subsequently characterized by electron microscopy, restriction enzyme mapping and partial DNA sequencing. This fragment contains a 400 base sequence which is homologous to that of an immunoglobulin light lambda chain mRNA which spans 3.3 to 3.7 kilobases from one end of the fragment. Restriction enzyme mapping as well as partial nucleotide sequencing of the 3' terminal of the homology region confirm the previous conclusion [Tonegawa, Brack, Hozumi and Schuller, Proc. Natl. Acad. Sci. USA. 74, 3518-3522 (1977)] that the cloned DNA fragment contains a Vlambda gene sequence which is separate from any Clambda sequence.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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