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. 1979 Nov 10;7(5):1311–1320. doi: 10.1093/nar/7.5.1311

Novobiocin; an inhibitor of the repair of UV-induced but not X-ray-induced damage in mammalian cells.

A Collins, R Johnson
PMCID: PMC342304  PMID: 514814

Abstract

In addition to inhibiting replicative DNA synthesis in HeLa cells, novobiocin has a severe effect on the cellular response to UV irradiation, reducing the number of breaks made in pre-existing DNA by the excision repair process. The inhibition of UV repair by novobiocin is reflected in enhanced UV-killing of these cells. Rejoining of DNA after X irradiation is not impaired by novobiocin. The recognition and removal of UV damage may require unwinding of the DNA by gyrase, which--in bacteria--is the target for novobiocin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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