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. 1977 Jun;4(6):1881–1890. doi: 10.1093/nar/4.6.1881

Features of the structure of replicating and non-replicating chromatin in chicken erythroblasts.

D Hewish
PMCID: PMC342529  PMID: 896476

Abstract

The digestion by DNAase I of DNA synthesised by isolated chicken erythroblasts was examined in isolated nuclei. It was found that newly synthesised DNA was susceptible to DNAase I but matured to a relatively resistant form with increasing time after replication as observed in mammalian systems. The presence of trypsin in the digestion exposed all of the DNA to DNAase I action. Examination of the digestion products showed that the newly replicated DNA differed little from the more mature form in the structure of the DNA-protein complex but that the difference in susceptibility was probably a result of a differential rate of access of the DNAase to the new and old DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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