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. 1977 Oct;4(10):3573–3580. doi: 10.1093/nar/4.10.3573

DNA double-strand breaks and alkali-labile bonds produced by bleomycin.

L F Povirk, W Wübter, W Köhnlein, F Hutchinson
PMCID: PMC342673  PMID: 73164

Abstract

Both in linear T2 DNA, analyyzed by velocity sedimentation, and in supercoiled Col EL DNA, analyzed by gel electrophoresis, the number of double-strand breaks produced by bleomycin was directly propotional to the number of single-strand breaks and was far greater than the number expected from random coincidence of single-strand breaks, suggesting that the bleomycin-induced double-strand breaks occur as an independent event. In Col EL DNA, at least twice as many single-strand breaks were found under alkaline assay conditions as were found under neutral conditions, showing the production of alkaline-labile bonds by bleomycin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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