Abstract
Stability of aromatic phosphoramidates was studied using 2′,3′-O-dibenzoyluridine 5′-phosphoramidates and N,2′,3′-O-tribenzoylcytidine 5′-phosphate. The effect of dicyclohexylcarbodiimide in this mixture was investigated. Decomposition of the anilidate was slower in the presence of DCC.
Substituted anilidates of uridine 5′-phosphate were synthesized and the stability of these amidates in anhydrous pyridine was studied.
2′-O-Benzoyluridine 3′-phosphoranilidate and the corresponding β-naphthylidate were compared in their stabilities in anhydrous pyridine, 50% aqueous pyridine and 80% acetic acid. 2′-O-Benzoyluridine 3′-phosphoro-β-naphthylidate was used for synthesis of dinucleotides.
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Selected References
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