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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1984 Jul;81(13):4164–4168. doi: 10.1073/pnas.81.13.4164

Illegitimate recombination generates a class switch from C mu to C delta in an IgD-secreting plasmacytoma.

A C Gilliam, A Shen, J E Richards, F R Blattner, J F Mushinski, P W Tucker
PMCID: PMC345389  PMID: 6429663

Abstract

We present here the sequence characterization of a C mu----C delta immunoglobulin (Ig) heavy chain class switch. In the murine IgD-secreting plasmacytoma TEPC 1017, deletion of most of the mu switch recombination region (S mu) and the entire C mu gene occurred in the absence of switch region sequences 5' to C delta. This unique rearrangement resulted from an illegitimate recombination of sequences with only patchy homology to each other. The infrequent and variable nature of illegitimate recombination may explain the low frequency of IgD-secreting plasma cells in normal mouse tissues.

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Selected References

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