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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1982 Apr;79(7):2415–2419. doi: 10.1073/pnas.79.7.2415

Transmission by presynaptic spike-like depolarization in the squid giant synapse.

R Llinás, M Sugimori, S M Simon
PMCID: PMC346205  PMID: 6954549

Abstract

Synaptic transmission produced by artificially generated presynaptic depolarizations, having the same waveform as normal presynaptic action potentials, was studied in the squid giant synapse. These stimulated spikes produced synaptic transmission virtually indistinguishable from that obtained with the original presynaptic spike activation. The technique allows a direct determination of the onset and amplitude of the Ca current, ICa, triggered by the presynaptic action potential and the relationship between ICa and postsynaptic response. The results closely resemble theoretical predictions by a previously published model for synaptic transmission in this synapse and demonstrate that ICa occurs at the falling phase of the presynaptic spike.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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