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. 1982 May;79(9):2836–2839. doi: 10.1073/pnas.79.9.2836

Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.

W C Barker, M O Dayhoff
PMCID: PMC346301  PMID: 6283546

Abstract

The transforming protein sequences translated from the Rous avian and Moloney murine sarcoma virus src genes are shown to be related to the catalytic chain of bovine cAMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37). The avian transforming protein, also a protein kinase, shows greatest homology with the bovine protein kinase in the carboxyl-terminal half, where the protein kinase activity is localized. Moreover, lysine occurs in the inferred transforming protein sequences at the position homologous with the proposed ATP-binding lysine of the bovine protein kinase. This relationship is consistent with the hypothesis that the src genes originated in the host genomes, in which they are members of a superfamily of distantly related protein kinases that are normal constituents of mammalian cells. In the host, these sequences are much more highly conserved than in the viruses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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