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. 1982 May;79(9):2952–2956. doi: 10.1073/pnas.79.9.2952

Adult hemoglobins are synthesized in erythroid colonies in vitro derived from murine circulating hemopoietic progenitor cells during embryonic development.

P M Wong, B J Clarke, D H Carr, D H Chui
PMCID: PMC346326  PMID: 6953440

Abstract

Circulating peripheral blood cells and disaggregated yolk sac cells were obtained from normal mouse embryos as early as day 9 of gestation, prior to the formation of the fetal liver. These were cultured in vitro in plasma clots or methylcellulose, in the presence of either embryonic fluid or adult spleen cell-conditioned medium, with or without added erythropoietin. Large erythroid colonies were observed by the sixth day of culture. In all instances, these erythroid colonies synthesized adult hemoglobins. These results indicate that erythroid progenitor cells committed to adult hemoglobin synthesis are present in early embryonic circulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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